ENSGALG00000036677


Gallus gallus

Features
Gene ID: ENSGALG00000036677
  
Biological name :ITSN1
  
Synonyms : intersectin 1 / ITSN1
  
Possible biological names infered from orthology : Q15811 / Q9Z0R4
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 105492244
Gene end: 105575073
  
Corresponding Affymetrix probe sets: Gga.18825.1.S1_at (Chicken Array)   Gga.9847.1.S1_s_at (Chicken Array)   GgaAffx.10196.1.S1_s_at (Chicken Array)   GgaAffx.10196.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047474
Ensembl peptide - ENSGALP00000055238
Ensembl peptide - ENSGALP00000049372
NCBI entrez gene - 418506     See in Manteia.
RefSeq - XM_416715
RefSeq - XM_015300003
RefSeq - XM_015300017
RefSeq - XM_015300022
RefSeq - XM_004934531
RefSeq - XM_015299993
RefSeq - XM_015299996
swissprot - A0A1D5PQS1
swissprot - A0A1D5P9G9
swissprot - A0A1D5P467
Ensembl - ENSGALG00000036677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itsn1ENSDARG00000000086Danio rerio
 ITSN1ENSG00000205726Homo sapiens
 Itsn1ENSMUSG00000022957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITSN2 / intersectin 2 / Q9NZM3*ENSGALG0000001650459
EPS15L1 / epidermal growth factor receptor pathway substrate 15 like 1 / Q60902* / Q9UBC2* / Epidermal growth factor receptor substrate 15-like 1 *ENSGALG0000002160111
EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*ENSGALG0000001054311
REPS1 / ralBP1-associated Eps domain-containing protein 1 / O54916* / Q96D71* / RALBP1 associated Eps domain containing 1*ENSGALG000000138297
EHD3 / EH domain-containing protein 3 / Q9NZN3* / Q9QXY6* / EH domain containing 3*ENSGALG000000090866
REPS2 / ralBP1-associated Eps domain-containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSGALG000000165455
EHD4 / EH domain containing 4 / Q9EQP2* / Q9H223* / EH domain-containing protein 4 *ENSGALG000000089505
SRL / sarcalumenin precursor / Q7TQ48* / Q86TD4* / sarcalumenin*ENSGALG000000388843


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000219  Dbl homology (DH) domain
 IPR000261  EH domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019209 kinase activator activity IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0070064 proline-rich region binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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