ENSDARG00000075853


Danio rerio

Features
Gene ID: ENSDARG00000075853
  
Biological name :sh3kbp1
  
Synonyms : SH3-domain kinase binding protein 1 / sh3kbp1
  
Possible biological names infered from orthology : Q8R550 / Q96B97 / SH3 domain containing kinase binding protein 1
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 25794318
Gene end: 25903017
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000101198
Ensembl peptide - ENSDARP00000120586
swissprot - E7FAT0
swissprot - E9QJP6
ZFIN ID - ZDB-GENE-091204-186
Ensembl - ENSDARG00000075853
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH3KBP1ENSGALG00000016420Gallus gallus
 Q96B97ENSG00000147010Homo sapiens
 Q8R550ENSMUSG00000040990Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cd2ap / CD2-associated protein / Q9JLQ0* / Q9Y5K6*ENSDARG0000001522427
sh3d21 / SH3 domain containing 21 / A4FU49* / Q7TSG5*ENSDARG0000009944814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0072554 blood vessel lumenization IMP


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
dorsal aorta blood vessel lumenization decreased process quality , abnormal
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 ZFA:0009044 blood cell blood cell accumulation sinus venosus , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex / reaction
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / complex / reaction
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / reaction / complex
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex






 

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