ENSMUSG00000040990


Mus musculus

Features
Gene ID: ENSMUSG00000040990
  
Biological name :Sh3kbp1
  
Synonyms : Q8R550 / SH3 domain-containing kinase-binding protein 1 / Sh3kbp1
  
Possible biological names infered from orthology : Q96B97
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F4
Gene start: 159627272
Gene end: 159978069
  
Corresponding Affymetrix probe sets: 10602840 (MoGene1.0st)   1431592_a_at (Mouse Genome 430 2.0 Array)   1432269_a_at (Mouse Genome 430 2.0 Array)   1456261_at (Mouse Genome 430 2.0 Array)   1460337_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114262
Ensembl peptide - ENSMUSP00000108075
Ensembl peptide - ENSMUSP00000114799
Ensembl peptide - ENSMUSP00000117618
Ensembl peptide - ENSMUSP00000072840
Ensembl peptide - ENSMUSP00000079257
Ensembl peptide - ENSMUSP00000108070
Ensembl peptide - ENSMUSP00000108072
NCBI entrez gene - 58194     See in Manteia.
MGI - MGI:1889583
RefSeq - XM_017318586
RefSeq - XM_006528926
RefSeq - XM_006528927
RefSeq - XM_006528928
RefSeq - XM_006528929
RefSeq - XM_006528932
RefSeq - XM_011247849
RefSeq - XM_011247851
RefSeq - XM_017318584
RefSeq - XM_017318585
RefSeq - NM_001135727
RefSeq - NM_001135728
RefSeq - NM_001290664
RefSeq - NM_021389
RefSeq - XM_006528924
RefSeq - XM_006528925
RefSeq Peptide - NP_067364
RefSeq Peptide - NP_001129199
RefSeq Peptide - NP_001129200
RefSeq Peptide - NP_001277593
swissprot - B0R0Y8
swissprot - Q8R550
swissprot - B1AZ85
swissprot - Q3TA88
swissprot - E9Q0C1
Ensembl - ENSMUSG00000040990
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3kbp1ENSDARG00000075853Danio rerio
 SH3KBP1ENSGALG00000016420Gallus gallus
 Q96B97ENSG00000147010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd2ap / Q9JLQ0 / CD2-associated protein / Q9Y5K6*ENSMUSG0000006166535
Q7TSG5 / Sh3d21 / SH3 domain containing 21 / A4FU49*ENSMUSG0000007375820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR035770  SH3 domain-containing kinase-binding protein 1, first SH3 domain
 IPR035771  SH3 domain-containing kinase-binding protein 1, second SH3 domain
 IPR035772  SH3 domain-containing kinase-binding protein 1, third SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0016477 cell migration ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Reelin signalling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: S100a8tm1Hogg/S100a8tm1Hogg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0010228 decreased transitional stage T3 B cell number "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6 * NZB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000042453 Reln / Q60841 / Reelin / P78509*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000028519 Dab1 / P97318 / Disabled homolog 1 / O75553* / DAB1, reelin adaptor protein*  / reaction / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / complex
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / reaction / complex






 

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