ENSMUSG00000028519


Mus musculus

Features
Gene ID: ENSMUSG00000028519
  
Biological name :Dab1
  
Synonyms : Dab1 / Disabled homolog 1 / P97318
  
Possible biological names infered from orthology : DAB1, reelin adaptor protein / O75553
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 103619359
Gene end: 104744844
  
Corresponding Affymetrix probe sets: 10506433 (MoGene1.0st)   1421100_a_at (Mouse Genome 430 2.0 Array)   1427307_a_at (Mouse Genome 430 2.0 Array)   1427308_at (Mouse Genome 430 2.0 Array)   1435577_at (Mouse Genome 430 2.0 Array)   1435578_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118650
Ensembl peptide - ENSMUSP00000118532
Ensembl peptide - ENSMUSP00000125033
Ensembl peptide - ENSMUSP00000102439
Ensembl peptide - ENSMUSP00000102440
Ensembl peptide - ENSMUSP00000102443
NCBI entrez gene - 13131     See in Manteia.
MGI - MGI:108554
RefSeq - XM_017319951
RefSeq - XM_011240432
RefSeq - XM_011240433
RefSeq - XM_011240434
RefSeq - XM_011240435
RefSeq - XM_017319948
RefSeq - XM_017319949
RefSeq - XM_017319950
RefSeq - NM_010014
RefSeq - NM_177259
RefSeq - XM_006502725
RefSeq - XM_006502726
RefSeq - XM_006502727
RefSeq - XM_006502735
RefSeq - XM_011240425
RefSeq - XM_011240426
RefSeq - XM_011240427
RefSeq - XM_011240428
RefSeq - XM_011240429
RefSeq - XM_011240430
RefSeq - XM_011240431
RefSeq Peptide - NP_034144
RefSeq Peptide - NP_796233
swissprot - B2RRQ8
swissprot - F2Z465
swissprot - A0A0A0MQI4
swissprot - P97318
swissprot - F6VRL0
Ensembl - ENSMUSG00000028519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DAB1ENSGALG00000010857Gallus gallus
 DAB1ENSG00000173406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dab2 / DAB2, clathrin adaptor protein / P98082*ENSMUSG0000002215036


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007162 negative regulation of cell adhesion IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0021517 ventral spinal cord development IEP
 biological_processGO:0021589 cerebellum structural organization IMP
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration IMP
 biological_processGO:0021942 radial glia guided migration of Purkinje cell IMP
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IGI
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0048712 negative regulation of astrocyte differentiation IMP
 biological_processGO:0050771 negative regulation of axonogenesis IMP
 biological_processGO:0051645 Golgi localization IMP
 biological_processGO:0097477 lateral motor column neuron migration IMP
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IGI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0042169 SH2 domain binding TAS
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA


Pathways (from Reactome)
Pathway description
Reelin signalling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Dab1tm1Cpr/Dab1tm4Cpr,Relnrl/Reln+
Genetic Background: involves: 129/Sv * C3HeB/Fe * C57BL/6

Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

Allelic Composition: Dab1tm1Cpr/Dab1tm4Cpr,Relnrl/Reln+
Genetic Background: involves: 129/Sv * C3HeB/Fe * C57BL/6

Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm3.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr,Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1

Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Gad1tm1Tama/?,Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Dab1scm-3J/Dab1scm-3J
Genetic Background: B6.Cg-Dab1scm-3J/J

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Dab1scm-3J/Dab1scm-3J
Genetic Background: B6.Cg-Dab1scm-3J/J

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm-3J/Dab1scm-3J
Genetic Background: B6.Cg-Dab1scm-3J/J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Park7tm1Cai/Park7tm1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ednratm2Ywa/Ednratm2Ywa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1.1Bwh/Dab1tm1.1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm2Ywa/Ednratm2Ywa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Ednratm2Ywa/Ednratm2Ywa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

Allelic Composition: Dab1tm2.1Cpr/Dab1tm2.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Dab1tm1.1Bwh/Dab1tm1.1Bwh
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nudt1tm1Tts/Nudt1tm1Tts
Genetic Background: B6.129S-Nudt1tm1Tts

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nudt1tm1Tts/Nudt1tm1Tts
Genetic Background: B6.129S-Nudt1tm1Tts

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nudt1tm1Tts/Nudt1tm1Tts
Genetic Background: B6.129S-Nudt1tm1Tts

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dab1tm1Cpr/Dab1tm3.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Cux2tm2.1(cre)Mull/Cux2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
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Allelic Composition: Nudt1tm1Tts/Nudt1tm1Tts
Genetic Background: B6.129S-Nudt1tm1Tts

 MP:0008265 abnormal hippocampus CA2 region morphology 
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Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Dab1tm1Cpr/Dab1tm3.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dab1tm2Cpr/Dab1tm2Cpr
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr,Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
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Allelic Composition: Dab1tm5Cpr/Dab1tm5Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dab1tm6Cpr/Dab1tm6Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008443 absent subplate "absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Cux2tm2.1(cre)Mull/Cux2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab1scm/Dab1scm
Genetic Background: involves: C3HeB/FeJ * DC/Le

 MP:0009949 abnormal olfactory bulb granule cell layer morphology 
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Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr
Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dab1scm-6J/Dab1scm-6J
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dab1scm-3J/Dab1scm-3J
Genetic Background: B6.Cg-Dab1scm-3J/J

Allelic Composition: Dab1scm-4J/Dab1scm-4J
Genetic Background: CBA/J-Dab1scm-4J/GrsrJ

Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0013138 thin body "lean or slender in form" [MGI:Ahmad_Retha]
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Allelic Composition: Dab1scm-5J/Dab1scm-5J
Genetic Background: BKS(Cg)-Dab1scm-5J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction
 ENSMUSG00000042453 Reln / Q60841 / Reelin / P78509*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction / complex






 

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