ENSMUSG00000022150


Mus musculus

Features
Gene ID: ENSMUSG00000022150
  
Biological name :Dab2
  
Synonyms : Dab2 / DAB2, clathrin adaptor protein
  
Possible biological names infered from orthology : P98082
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 6299788
Gene end: 6440712
  
Corresponding Affymetrix probe sets: 10422728 (MoGene1.0st)   10422744 (MoGene1.0st)   1420498_a_at (Mouse Genome 430 2.0 Array)   1423805_at (Mouse Genome 430 2.0 Array)   1429693_at (Mouse Genome 430 2.0 Array)   1430604_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106292
Ensembl peptide - ENSMUSP00000125696
Ensembl peptide - ENSMUSP00000125452
Ensembl peptide - ENSMUSP00000125021
Ensembl peptide - ENSMUSP00000124996
Ensembl peptide - ENSMUSP00000124589
Ensembl peptide - ENSMUSP00000124478
Ensembl peptide - ENSMUSP00000124145
Ensembl peptide - ENSMUSP00000077166
Ensembl peptide - ENSMUSP00000079689
Ensembl peptide - ENSMUSP00000106291
NCBI entrez gene - 13132     See in Manteia.
MGI - MGI:109175
RefSeq - XM_017316424
RefSeq - NM_001008702
RefSeq - NM_001037905
RefSeq - NM_001102400
RefSeq - NM_001310446
RefSeq - NM_023118
RefSeq - XM_011245324
RefSeq Peptide - NP_001297375
RefSeq Peptide - NP_001008702
RefSeq Peptide - NP_001032994
RefSeq Peptide - NP_001095870
RefSeq Peptide - NP_075607
swissprot - E0CYJ2
swissprot - E0CXT5
swissprot - A0A1Y7VGS2
swissprot - A0A0R4J104
swissprot - E9PX84
swissprot - F6TQN9
swissprot - Q3TRE6
swissprot - Q9DCE6
swissprot - E9QL31
swissprot - E0CZ53
Ensembl - ENSMUSG00000022150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dab2ENSDARG00000031761Danio rerio
 si:ch211-204c21.1ENSDARG00000053091Danio rerio
 DAB2ENSGALG00000003803Gallus gallus
 DAB2ENSG00000153071Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dab1 / P97318 / Disabled homolog 1 / O75553* / DAB1, reelin adaptor protein*ENSMUSG0000002851926


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035026 leading edge cell differentiation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis IEA
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070022 transforming growth factor beta receptor complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0038024 cargo receptor activity IEA
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Tg(Ins2-cre)25Mgn/0,Tg(Ins2-Irs2)13Mfw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011201 abnormal visceral yolk sac cavity morphology "any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm)" [ISBN:0-12-402035-6, PMID:21123814]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011208 small proamniotic cavity "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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