ENSG00000153071


Homo sapiens

Features
Gene ID: ENSG00000153071
  
Biological name :DAB2
  
Synonyms : DAB2 / DAB2, clathrin adaptor protein / P98082
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.1
Gene start: 39371675
Gene end: 39462300
  
Corresponding Affymetrix probe sets: 1559370_at (Human Genome U133 Plus 2.0 Array)   201278_at (Human Genome U133 Plus 2.0 Array)   201279_s_at (Human Genome U133 Plus 2.0 Array)   201280_s_at (Human Genome U133 Plus 2.0 Array)   210757_x_at (Human Genome U133 Plus 2.0 Array)   232898_at (Human Genome U133 Plus 2.0 Array)   240873_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345508
Ensembl peptide - ENSP00000439919
Ensembl peptide - ENSP00000427541
Ensembl peptide - ENSP00000426245
Ensembl peptide - ENSP00000425088
Ensembl peptide - ENSP00000421526
Ensembl peptide - ENSP00000421086
Ensembl peptide - ENSP00000313391
NCBI entrez gene - 1601     See in Manteia.
OMIM - 601236
RefSeq - NM_001244871
RefSeq - NM_001343
RefSeq Peptide - NP_001231800
RefSeq Peptide - NP_001334
swissprot - D6RIA5
swissprot - P98082
swissprot - D6RGZ1
swissprot - D6RFF7
swissprot - D6REB1
swissprot - A0A024R036
Ensembl - ENSG00000153071
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dab2ENSDARG00000031761Danio rerio
 si:ch211-204c21.1ENSDARG00000053091Danio rerio
 DAB2ENSGALG00000003803Gallus gallus
 Dab2ENSMUSG00000022150Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAB1 / O75553 / DAB1, reelin adaptor proteinENSG0000017340626


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035026 leading edge cell differentiation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045807 positive regulation of endocytosis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IDA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISS
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis IMP
 biological_processGO:2000643 positive regulation of early endosome to late endosome transport IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070022 transforming growth factor beta receptor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0035615 clathrin adaptor activity IMP
 molecular_functionGO:0038024 cargo receptor activity IMP
 molecular_functionGO:0046332 SMAD binding IDA


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130164 LDLR / P01130 / low density lipoprotein receptor  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000196586 MYO6 / Q9UM54 / myosin VI  / reaction / complex
 ENSG00000081479 LRP2 / P98164 / LDL receptor related protein 2  / reaction / complex






 

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