ENSMUSG00000020122


Mus musculus

Features
Gene ID: ENSMUSG00000020122
  
Biological name :Egfr
  
Synonyms : Egfr / Epidermal growth factor receptor / Q01279
  
Possible biological names infered from orthology : P00533
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A2
Gene start: 16752203
Gene end: 16918158
  
Corresponding Affymetrix probe sets: 10374366 (MoGene1.0st)   1424932_at (Mouse Genome 430 2.0 Array)   1432647_at (Mouse Genome 430 2.0 Array)   1435888_at (Mouse Genome 430 2.0 Array)   1451530_at (Mouse Genome 430 2.0 Array)   1454313_at (Mouse Genome 430 2.0 Array)   1457563_at (Mouse Genome 430 2.0 Array)   1460420_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020329
Ensembl peptide - ENSMUSP00000099948
Ensembl peptide - ENSMUSP00000122632
NCBI entrez gene - 13649     See in Manteia.
MGI - MGI:95294
RefSeq - NM_207655
RefSeq - NM_007912
RefSeq Peptide - NP_031938
RefSeq Peptide - NP_997538
swissprot - Q01279
swissprot - Q5SVE7
swissprot - Q9WVF5
Ensembl - ENSMUSG00000020122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGFRENSGALG00000038089Gallus gallus
 EGFRENSG00000146648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220953
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231251
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816642
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260716
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945616
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279114
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145713
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611712
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006898 receptor-mediated endocytosis ISO
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007435 salivary gland morphogenesis IMP
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010750 positive regulation of nitric oxide mediated signal transduction IEA
 biological_processGO:0010960 magnesium ion homeostasis IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0033594 response to hydroxyisoflavone IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060571 morphogenesis of an epithelial fold IMP
 biological_processGO:0061029 eyelid development in camera-type eye IGI
 biological_processGO:0070141 response to UV-A IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900020 positive regulation of protein kinase C activity IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1902722 positive regulation of prolactin secretion IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1905208 negative regulation of cardiocyte differentiation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097489 multivesicular body, internal vesicle lumen IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005006 epidermal growth factor-activated receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048408 epidermal growth factor binding IDA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
Signal transduction by L1
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Rorbtm1Mba/Rorbtm1Mba
Genetic Background: involves: 129P2/OlaHsd

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfrtm1Mag,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Egfrtm1.1Dwt/Egfrtm1.1Dwt
Genetic Background: involves: 129S6/SvEvTac

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0000384 distorted hair follicle pattern "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000396 increased curvature of hairs "distinct C- or S- shaped curvature of the hairs" [J:4606]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0000399 increased curvature of guard hairs "greater bending arch of the guard hairs" [J:47620]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: EgfrMhdadsk5/EgfrMhdadsk5
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Egfrwa2-4J/Egfrwa2-4J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000446 long snout "the anterior facial part of the muzzle having a length greater than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: EgfrMhdadsk5/EgfrMhdadsk5
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0000583 long toenails "increased length of the toenails" [J:65045]
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Allelic Composition: EgfrMhdadsk5/EgfrMhdadsk5
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Egfrtm1.1Dwt/Egfrtm1.1Dwt
Genetic Background: involves: 129S6/SvEvTac

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Egfrtm1.1Dwt/Egfrtm1.1Dwt
Genetic Background: involves: 129S6/SvEvTac

 MP:0001142 abnormal vaginal opening "a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Relntm1.1Mhat/Relntm1.1Mhat
Genetic Background: B6NSlc.B6(Cg)-Relntm1.1Mhat

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrwa2/Egfrwa2,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: EgfrMhdadsk5/EgfrMhdadsk5
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0001221 epidermal atrophy "wasting of the epidermal layer of the skin" [J:65033]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6 * MF1

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0001279 wavy vibrissae "whiskers having undulations or a sinusoidal shape" [J:65044]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001280 loss of vibrissae "inability to retain the whiskers" [J:45400]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0001316 corneal scarring "appearance of fibrous tissue on the cornea after healing in response to injury " [J:30249]
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Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relntm1.1Mhat/Relntm1.1Mhat
Genetic Background: B6NSlc.B6(Cg)-Relntm1.1Mhat

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001711 abnormal placenta 
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * NOD

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Col6a1tm1Gmb/Col6a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: EgfrWa5/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: EgfrWa5/Egfr+,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm6.1Wag/Fostm6.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm3.1Wag/Fostm3.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Rps6ka3tm1.1Kry/Y,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Egfrwa2/Egfr+,Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Egfrwa2/Egfr+,Fostm4.1Wag/Fostm4.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: EgfrWa5/Egfr+,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrwa2/Egfr+,Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrwa2/Egfrwa2,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002268 abnormal terminal bronchiole morphology "any structural anomaly of the last conducting structure of bronchioles; after this point, the airways have alveoli in their walls " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm3.1Wag/Fostm3.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Rps6ka3tm1.1Kry/Y,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Egfrwa2/Egfr+,Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfr+,Fostm6.1Wag/Fostm6.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Egfrtm1Dwt/Egfrtm1Dwt,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: EgfrWa5/Egfr+,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col6a1tm1Gmb/Col6a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005099 abnormal ciliary body morphology "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6 * MF1

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Egfrtm1Msi/Egfrtm1Msi,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006026 dilated terminal bronchiole tubes "increased volume of the terminal lung buds" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006116 aortic valve calcification "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006257 abnormal fungiform papillae "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single tase bud at the tip, located mostly on the dorsal anterior portion of the tongue " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006265 increased pulse pressure "increase in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Egfrtm1Msi/Egfrtm1Msi,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfr+,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0008862 asymmetric snout "presence of a snout that lacks mirrored identity on either side of the median plane" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0008899 plush coat "coat has a thick, velvet-like appearance" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Egfrtm1Msi/Egfrtm1Msi,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009801 abnormal hair cortex keratinization "any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relntm1.1Mhat/Relntm1.1Mhat
Genetic Background: B6NSlc.B6(Cg)-Relntm1.1Mhat

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK Egfrwa2

 MP:0010570 prolonged ST segment "increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: STOCK ac

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrtm1Mag/Egfrwa2
Genetic Background: involves: 129S2/SvPas * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * CD-1

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0010898 abnormal pulmonary alveolus epithelium morphology "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Chuktm1Yhu/Chuktm1Yhu,Egfrtm1Mag/Egfrtm1Mag,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6 * MF1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Egfrtm1Mag/Egfrtm1Mag
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Rbn/Ptpn11+
Genetic Background: involves: 129 * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Egfrtm1Wag/Egfrtm2(EGFR)Wag
Genetic Background: 129/Sv

Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: 129/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tnnt3tm2a(KOMP)Wtsi/Tnnt3tm2a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: EgfrVel/EgfrVel
Genetic Background: involves: C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: EgfrWa5/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: EgfrWa5/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: EgfrVel/Egfr+
Genetic Background: involves: C57BL/6J

 MP:0011710 increased osteoblast differentiation 
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011926 abnormal cardiac valve physiology 
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Dsg3tm1Stan/Dsg3tm1Stan
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: EgfrWa5/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: EgfrWa5/Egfr+
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

Allelic Composition: Egfrtm1Wag/Egfrtm1Wag
Genetic Background: involves: 129 * C57BL/6

 MP:0013542 abnormal submandibular gland branching morphogenesis 
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0014107 premature chondrocyte differentiation "early occurance of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030026 small Meckel s cartilage "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: Egfrtm1Rdk/Egfrtm1Rdk
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0030191 narrow snout "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Egfrwa2/EgfrWa5
Genetic Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001036 Epn2 / Q8CHU3 / Epsin-2 / O95208*  / reaction / complex
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000026126 Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / complex
 ENSMUSG00000037211 Spry1 / Q9QXV9 / sprouty RTK signaling antagonist 1 / O43609*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000029816 Gpnmb / Q99P91 / Transmembrane glycoprotein NMB / Q14956* / glycoprotein nmb*  / reaction / complex
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex / reaction
 ENSMUSG00000036273 Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000028552 Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000035203 Epn1 / Q80VP1 / Epsin-1 / Q9Y6I3*  / complex / reaction
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / complex / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex






 

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