ENSMUSG00000031714


Mus musculus

Features
Gene ID: ENSMUSG00000031714
  
Biological name :Gab1
  
Synonyms : Gab1 / GRB2-associated-binding protein 1 / Q9QYY0
  
Possible biological names infered from orthology : Q13480
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 80764438
Gene end: 80880519
  
Corresponding Affymetrix probe sets: 10579925 (MoGene1.0st)   1417693_a_at (Mouse Genome 430 2.0 Array)   1417694_at (Mouse Genome 430 2.0 Array)   1448814_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034150
Ensembl peptide - ENSMUSP00000147784
NCBI entrez gene - 14388     See in Manteia.
MGI - MGI:108088
RefSeq - XM_017312576
RefSeq - NM_001301298
RefSeq - NM_021356
RefSeq - XM_006530676
RefSeq - XM_006530677
RefSeq - XM_011248309
RefSeq - XM_011248310
RefSeq - XM_017312575
RefSeq - XM_006530674
RefSeq Peptide - NP_001288227
RefSeq Peptide - NP_067331
swissprot - Q505A4
swissprot - Q9QYY0
swissprot - A0A1B0GS41
Ensembl - ENSMUSG00000031714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gab1ENSDARG00000037018Danio rerio
 GAB1ENSGALG00000009898Gallus gallus
 GAB1ENSG00000109458Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*ENSMUSG0000000450835
Gab3 / Q8BSM5 / GRB2-associated-binding protein 3 / Q8WWW8*ENSMUSG0000003275023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0030334 regulation of cell migration IGI
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0035728 response to hepatocyte growth factor IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway ISO
 biological_processGO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 biological_processGO:0090668 endothelial cell chemotaxis to vascular endothelial growth factor ISO
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hap1tm1Hay/Hap1tm1Hay
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hap1tm1Hay/Hap1tm1Hay
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm,Mettm1Cbm/Mettm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gab1tm1Gsf/Gab1tm1Gsf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Gab1tm1Wbm/Gab1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gab1tm5Wbm/Gab1tm5Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm3Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Gab1tm2Wbm/Gab1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030208 abnormal intrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000020740 Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000044147 Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex






 

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