Manteia - Molecule gene

ENSMUSG00000000182

Mus musculus

Features

Gene ID:	ENSMUSG00000000182

Biological name :	Fgf23

Synonyms :	Fgf23 / Fibroblast growth factor 23 / Q9EPC2

Possible biological names infered from orthology :	Q9GZV9

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	F3
Gene start:	127072902
Gene end:	127081408

Corresponding Affymetrix probe sets:	10542028 (MoGene1.0st) 1422176_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000000186 NCBI entrez gene - 64654 See in Manteia. MGI - MGI:1891427 RefSeq - NM_022657 RefSeq Peptide - NP_073148 swissprot - Q3U1V5 swissprot - Q9EPC2 Ensembl - ENSMUSG00000000182

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fgf23	ENSDARG00000045854	Danio rerio
FGF23	ENSGALG00000027791	Gallus gallus
FGF23	ENSG00000118972	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fgf21 / Q9JJN1 / Fibroblast growth factor 21 / Q9NSA1*	ENSMUSG00000030827	25
Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*	ENSMUSG00000031073	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF
IPR028304	Fibroblast growth factor 23

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IDA
biological_process	GO:0006796	phosphate-containing compound metabolic process	IEA
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	IEA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010966	regulation of phosphate transport	IEA
biological_process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030500	regulation of bone mineralization	IMP
biological_process	GO:0030502	negative regulation of bone mineralization	IEA
biological_process	GO:0030643	cellular phosphate ion homeostasis	IMP
biological_process	GO:0032026	response to magnesium ion	IEA
biological_process	GO:0042359	vitamin D metabolic process	IEA
biological_process	GO:0042369	vitamin D catabolic process	ISO
biological_process	GO:0044320	cellular response to leptin stimulus	IEA
biological_process	GO:0045668	negative regulation of osteoblast differentiation	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0046888	negative regulation of hormone secretion	ISS
biological_process	GO:0055062	phosphate ion homeostasis	ISO
biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA
biological_process	GO:0071305	cellular response to vitamin D	IEA
biological_process	GO:0071354	cellular response to interleukin-6	IEA
biological_process	GO:0071374	cellular response to parathyroid hormone stimulus	IEA
biological_process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI
biological_process	GO:1904383	response to sodium phosphate	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005623	cell	IEA
molecular_function	GO:0005104	fibroblast growth factor receptor binding	IEA
molecular_function	GO:0005105	type 1 fibroblast growth factor receptor binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

PIP3 activates AKT signaling

FGFR4 ligand binding and activation

FGFR3c ligand binding and activation

FGFR1c ligand binding and activation

FGFR1c and Klotho ligand binding and activation

FGFR2c ligand binding and activation

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Phospholipase C-mediated cascade: FGFR1

Phospholipase C-mediated cascade; FGFR2

Phospholipase C-mediated cascade; FGFR3

Phospholipase C-mediated cascade; FGFR4

Downstream signaling of activated FGFR1

SHC-mediated cascade:FGFR1

PI-3K cascade:FGFR1

FRS-mediated FGFR1 signaling

PI-3K cascade:FGFR2

SHC-mediated cascade:FGFR2

FRS-mediated FGFR2 signaling

SHC-mediated cascade:FGFR3

FRS-mediated FGFR3 signaling

PI-3K cascade:FGFR3

FRS-mediated FGFR4 signaling

SHC-mediated cascade:FGFR4

PI-3K cascade:FGFR4

Negative regulation of FGFR1 signaling

Negative regulation of FGFR2 signaling

Negative regulation of FGFR3 signaling

Negative regulation of FGFR4 signaling

FGFRL1 modulation of FGFR1 signaling

RAF/MAP kinase cascade

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000061	fragile skeleton	"easily damaged or broken bones" [J:14208]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000132	thickened epiphysis	"wider than normal part of the long bones that initially develops from a distinct ossification center than the shaft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000167	reduced chondrocyte numbers	"fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0000194	hypercalcemia	"abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0000198	hypophosphatemia	"abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew Allelic Composition: Fgf23^tm1.1Kew/Fgf23⁺ Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0000462	abnormal digestive system morphology	"anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Phb^tm1.1Bwo/Phb^tm1.1Bwo,Pgr^tm2(cre)Lyd/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129 * C57BL/6
MP:0001562	abnormal circulating calcium level	"anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001565	abnormal circulating phosphate level	"anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001566	hyperphosphatemia	"abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129 * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001958	emphysema	"lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129 * C57BL/6
MP:0002089	abnormal postnatal growth/weight/body size	"increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002160	abnormal reproductive system morphology	"structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002264	abnormal bronchus morphology	"any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0002904	increased circulating parathyroid hormone level	"greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: H2-DMa^tm1Luc/H2-DMa^tm1Luc Genetic Background: B6.129S4-H2-Dma^tm1Luc
MP:0002905	decreased circulating parathyroid hormone level	"less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Vdr^tm1Rge/Vdr^tm1Rge Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew Allelic Composition: Fgf23^tm1.1Kew/Fgf23⁺ Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Blan/Fgf23⁺,Phex^Hyp/Y Genetic Background: Not Specified Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003116	rickets	"overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003197	kidney calcification	"pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6
MP:0003414	epidermal cyst	"a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Vdr^tm1Rge/Vdr^tm1Rge Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003795	abnormal bone structure		Show Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0004348	long femur	"increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005265	abnormal blood urea nitrogen level	"aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005419	hypoalbuminemia	"blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6
MP:0005636	abnormal mineral homeostasis	"anomaly in the state of equilibrium in the body with respect to any of the inorganic substance that have importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0006133	arterial calcification	"pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan Genetic Background: involves: 129 * C57BL/6
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0008152	decreased diameter of femur	"reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan,Phex^Hyp/Y Genetic Background: Not Specified
MP:0008158	increased diameter of femur	"increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23⁺,Phex^Hyp/Y Genetic Background: Not Specified
MP:0009445	osteomalacia	"gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0010110	abnormal renal phosphate reabsorption	"any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: Not Specified
MP:0010924	abnormal osteoid morphology	"any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0010929	increased osteoid thickness	"increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0011228	abnormal vitamin D level	"any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]	Show Allelic Composition: Ass1^tm1Bay/Ass1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgf23^tm1Sliu/Fgf23⁺,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu,Phex^Hyp/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1Sliu/Fgf23^tm1Sliu Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew Genetic Background: B6.129-Fgf23^tm1.1Kew
MP:0013616	decreased volumetric bone mineral density	"reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]	Show Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025499	Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*	/ reaction
ENSMUSG00000058488	Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*	/ complex / reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ complex / reaction
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ complex / reaction
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ complex / reaction
ENSMUSG00000030265	Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*	/ reaction
ENSMUSG00000000182	Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*	/ complex / reaction
ENSMUSG00000020170	Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*	/ complex / reaction
ENSMUSG00000042626	Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	/ complex / reaction
ENSMUSG00000016933	Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*	/ complex / reaction
ENSMUSG00000034342	Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*	/ complex / reaction
ENSMUSG00000027665	P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*	/ reaction / complex
ENSMUSG00000031714	Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*	/ complex / reaction
ENSMUSG00000026994	Galnt3 / P70419 / Polypeptide N-acetylgalactosaminyltransferase 3 / Q14435*	/ reaction
ENSMUSG00000041417	P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*	/ reaction / complex
ENSMUSG00000063358	Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*	/ reaction
ENSMUSG00000063065	Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*	/ reaction
ENSMUSG00000051379	Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*	/ reaction / complex
ENSMUSG00000047414	Flrt2 / Q8BLU0 / Leucine-rich repeat transmembrane protein FLRT2 / O43155* / fibronectin leucine rich transmembrane protein 2*	/ reaction / complex
ENSMUSG00000031565	Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*	/ complex / reaction
ENSMUSG00000047787	Flrt1 / Q6RKD8 / Leucine-rich repeat transmembrane protein FLRT1 / Q9NZU1* / fibronectin leucine rich transmembrane protein 1*	/ complex / reaction
ENSMUSG00000023266	Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*	/ complex / reaction

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr