ENSMUSG00000026994


Mus musculus

Features
Gene ID: ENSMUSG00000026994
  
Biological name :Galnt3
  
Synonyms : Galnt3 / P70419 / Polypeptide N-acetylgalactosaminyltransferase 3
  
Possible biological names infered from orthology : Q14435
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 66082766
Gene end: 66124994
  
Corresponding Affymetrix probe sets: 10483249 (MoGene1.0st)   1417588_at (Mouse Genome 430 2.0 Array)   1417589_at (Mouse Genome 430 2.0 Array)   1427749_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028378
NCBI entrez gene - 14425     See in Manteia.
MGI - MGI:894695
RefSeq - NM_015736
RefSeq Peptide - NP_056551
swissprot - P70419
Ensembl - ENSMUSG00000026994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GALNT3ENSDARG00000108649Danio rerio
 GALNT3ENSGALG00000010960Gallus gallus
 GALNT3ENSG00000115339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Galnt6 / Q8C7U7 / Polypeptide N-acetylgalactosaminyltransferase 6 / Q8NCL4*ENSMUSG0000003728064
Galnt4 / O08832 / Polypeptide N-acetylgalactosaminyltransferase 4 / Q8N4A0* / POC1B-GALNT4* / POC1B-GALNT4 readthrough*ENSMUSG0000009003541
Q8CF93 / Galnt13 / Polypeptide N-acetylgalactosaminyltransferase 13 / Q8IUC8*ENSMUSG0000006098838
Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*ENSMUSG0000000042038
Q8BGT9 / Galnt12 / Polypeptide N-acetylgalactosaminyltransferase 12 / Q8IXK2*ENSMUSG0000003977438
Q9JJ61 / Galnt16 / Polypeptide N-acetylgalactosaminyltransferase 16 / Q8N428*ENSMUSG0000002113034
Q921L8 / Galnt11 / Polypeptide N-acetylgalactosaminyltransferase 11 / Q8NCW6*ENSMUSG0000003807233
Galnt5 / Q8C102 / Polypeptide N-acetylgalactosaminyltransferase 5 / Q7Z7M9*ENSMUSG0000002682833
Galnt2 / Q6PB93 / Polypeptide N-acetylgalactosaminyltransferase 2 Polypeptide N-acetylgalactosaminyltransferase 2 soluble form / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*ENSMUSG0000008970432
Q8BVG5 / Galnt14 / Polypeptide N-acetylgalactosaminyltransferase 14 / Q96FL9*ENSMUSG0000002406432
Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*ENSMUSG0000009232932
Q9D4M9 / Galntl5 / Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 / Q7Z4T8* / polypeptide N-acetylgalactosaminyltransferase like 5*ENSMUSG0000002893824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000772  Ricin B, lectin domain
 IPR001173  Glycosyltransferase 2-like
 IPR029044  Nucleotide-diphospho-sugar transferases
 IPR035992  Ricin B-like lectins


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0018242 protein O-linked glycosylation via serine IEA
 biological_processGO:0018243 protein O-linked glycosylation via threonine IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
FGFR3c ligand binding and activation
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sema3atm1Mcf/Sema3atm1Mcf,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Galnt3tm1Mjec/Galnt3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3atm1Mcf/Sema3atm1Mcf,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003195 calcinosis "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0003196 skin calcification "pathologic deposition of calcium salts in the skin" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0010522 aorta calcification "pathologic deposition of calcium salts in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0010964 increased compact bone volume 
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0011585 decreased alkaline phosphatase activity "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0012337 increased vitamin D level "greater level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Galnt3tcal/Galnt3tcal
Genetic Background: involves: C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction






 

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