ENSMUSG00000000420


Mus musculus

Features
Gene ID: ENSMUSG00000000420
  
Biological name :Galnt1
  
Synonyms : Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
  
Possible biological names infered from orthology : polypeptide N-acetylgalactosaminyltransferase 1 / Q10472
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 24205344
Gene end: 24286818
  
Corresponding Affymetrix probe sets: 10454310 (MoGene1.0st)   1423236_at (Mouse Genome 430 2.0 Array)   1423237_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132411
Ensembl peptide - ENSMUSP00000132142
Ensembl peptide - ENSMUSP00000137427
Ensembl peptide - ENSMUSP00000000430
Ensembl peptide - ENSMUSP00000130238
Ensembl peptide - ENSMUSP00000131755
NCBI entrez gene - 14423     See in Manteia.
MGI - MGI:894693
RefSeq - XM_017317833
RefSeq - NM_001160404
RefSeq - NM_013814
RefSeq - XM_006525650
RefSeq Peptide - NP_001153876
RefSeq Peptide - NP_038842
swissprot - E9PVK6
swissprot - F6PYE1
swissprot - E9Q0U0
swissprot - O08912
Ensembl - ENSMUSG00000000420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 galnt1ENSDARG00000061335Danio rerio
 GALNT1ENSGALG00000013135Gallus gallus
 GALNT1ENSG00000141429Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CF93 / Galnt13 / Polypeptide N-acetylgalactosaminyltransferase 13 / Q8IUC8*ENSMUSG0000006098884
Galnt3 / P70419 / Polypeptide N-acetylgalactosaminyltransferase 3 / Q14435*ENSMUSG0000002699443
Galnt6 / Q8C7U7 / Polypeptide N-acetylgalactosaminyltransferase 6 / Q8NCL4*ENSMUSG0000003728043
Q921L8 / Galnt11 / Polypeptide N-acetylgalactosaminyltransferase 11 / Q8NCW6*ENSMUSG0000003807242
Galnt4 / O08832 / Polypeptide N-acetylgalactosaminyltransferase 4 / Q8N4A0* / POC1B-GALNT4* / POC1B-GALNT4 readthrough*ENSMUSG0000009003542
Galnt2 / Q6PB93 / Polypeptide N-acetylgalactosaminyltransferase 2 Polypeptide N-acetylgalactosaminyltransferase 2 soluble form / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*ENSMUSG0000008970441
Q8BGT9 / Galnt12 / Polypeptide N-acetylgalactosaminyltransferase 12 / Q8IXK2*ENSMUSG0000003977441
Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*ENSMUSG0000009232939
Q8BVG5 / Galnt14 / Polypeptide N-acetylgalactosaminyltransferase 14 / Q96FL9*ENSMUSG0000002406438
Q9JJ61 / Galnt16 / Polypeptide N-acetylgalactosaminyltransferase 16 / Q8N428*ENSMUSG0000002113037
Galnt5 / Q8C102 / Polypeptide N-acetylgalactosaminyltransferase 5 / Q7Z7M9*ENSMUSG0000002682835
Q9D4M9 / Galntl5 / Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 / Q7Z4T8* / polypeptide N-acetylgalactosaminyltransferase like 5*ENSMUSG0000002893829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000772  Ricin B, lectin domain
 IPR001173  Glycosyltransferase 2-like
 IPR029044  Nucleotide-diphospho-sugar transferases
 IPR035992  Ricin B-like lectins


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation ISO
 biological_processGO:0018242 protein O-linked glycosylation via serine ISO
 biological_processGO:0018243 protein O-linked glycosylation via threonine ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030145 manganese ion binding ISO
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPI-independent Golgi-to-ER retrograde traffic
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic Background: involves: 129 * C57BL/6

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / reaction / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex / reaction
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / reaction
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / reaction / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex / reaction
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex / reaction
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / reaction / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex / reaction
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / reaction / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / reaction / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex / reaction
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex / reaction
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex / reaction
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex / reaction
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / reaction / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex / reaction
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / reaction / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / reaction / complex






 

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