ENSMUSG00000018707


Mus musculus

Features
Gene ID: ENSMUSG00000018707
  
Biological name :Dync1h1
  
Synonyms : Cytoplasmic dynein 1 heavy chain 1 / Dync1h1 / Q9JHU4
  
Possible biological names infered from orthology : dynein cytoplasmic 1 heavy chain 1 / Q14204
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 110601452
Gene end: 110666945
  
Corresponding Affymetrix probe sets: 10398483 (MoGene1.0st)   1416648_at (Mouse Genome 430 2.0 Array)   1439950_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018851
Ensembl peptide - ENSMUSP00000126117
NCBI entrez gene - 13424     See in Manteia.
MGI - MGI:103147
RefSeq - NM_030238
RefSeq Peptide - NP_084514
swissprot - F6ZX84
swissprot - Q9JHU4
Ensembl - ENSMUSG00000018707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DYNC1H1ENSGALG00000011330Gallus gallus
 Q14204ENSG00000197102Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnah17 / dynein axonemal heavy chain 17 / Q9UFH2*ENSMUSG0000003398724
Dnah11 / dynein axonemal heavy chain 11 / Q96DT5*ENSMUSG0000001858124
Dnah5 / Q8VHE6 / Dynein heavy chain 5, axonemal ENSMUSG0000002226223
Dnah10ENSMUSG0000003801123
Dnah2 / P0C6F1 / Dynein heavy chain 2, axonemal / Q9P225* / dynein axonemal heavy chain 2*ENSMUSG0000000523723
Dnah1 / E9Q8T7 / Dynein heavy chain 1, axonemal / Q9P2D7* / dynein axonemal heavy chain 1*ENSMUSG0000001902722
Dnah8 / Q91XQ0 / Dynein heavy chain 8, axonemal / Q96JB1* / dynein axonemal heavy chain 8*ENSMUSG0000003382622
Dnah7a / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*ENSMUSG0000009614121
Dnah7c / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*ENSMUSG0000010133721
Dnah6 / dynein axonemal heavy chain 6 / Q9C0G6*ENSMUSG0000005286121
Dnah12ENSMUSG0000002187920
Dnah3 / Q8BW94 / Dynein heavy chain 3, axonemal ENSMUSG0000005227320
Dnah14 / Q0VDD8* / dynein axonemal heavy chain 14*ENSMUSG0000004736919


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR004273  Dynein heavy chain domain
 IPR011704  ATPase, dynein-related, AAA domain
 IPR013594  Dynein heavy chain, domain-1
 IPR013602  Dynein heavy chain, domain-2
 IPR024317  Dynein heavy chain, AAA module D4
 IPR024743  Dynein heavy chain, coiled coil stalk
 IPR026983  Dynein heavy chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035699  Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1
 IPR035706  Dynein heavy chain, ATP-binding dynein motor region D5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement IC
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IBA
 biological_processGO:0032388 positive regulation of intracellular transport IEA
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0034063 stress granule assembly IMP
 biological_processGO:0051293 establishment of spindle localization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060236 regulation of mitotic spindle organization IEA
 biological_processGO:0072382 minus-end-directed vesicle transport along microtubule IBA
 biological_processGO:0090235 regulation of metaphase plate congression IEA
 biological_processGO:1905832 positive regulation of spindle assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045505 dynein intermediate chain binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: C3H/HeH-Dync1h1Loa

Allelic Composition: Dync1h1Cra1/Dync1h1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Dync1h1Cra1/Dync1h1+
Genetic Background: C3HeB/FeJ-Dync1h1Cra1

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Dync1h1Cra1/Dync1h1+
Genetic Background: C3HeB/FeJ-Dync1h1Cra1

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Dync1h1Loa/Dync1h1+
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
Show

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
Show

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
Show

Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0005113 decreased number of anterior horn cells "fewer than the expected number of cells in the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009393 abnormal resting posture "atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Dync1h1Cra1/Dync1h1+
Genetic Background: C3HeB/FeJ-Dync1h1Cra1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dync1h1Loa/Dync1h1Loa
Genetic Background: C3H/HeH-Dync1h1Loa

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Grk6tm1.1Mca/Grk6+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove/Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove
Genetic Background: FVB/N-Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / complex / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / reaction / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / complex / reaction
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex






 

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