ENSMUSG00000019027


Mus musculus

Features
Gene ID: ENSMUSG00000019027
  
Biological name :Dnah1
  
Synonyms : Dnah1 / Dynein heavy chain 1, axonemal / E9Q8T7
  
Possible biological names infered from orthology : dynein axonemal heavy chain 1 / Q9P2D7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 31260375
Gene end: 31323896
  
Corresponding Affymetrix probe sets: 10418616 (MoGene1.0st)   1425307_at (Mouse Genome 430 2.0 Array)   1434594_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043281
NCBI entrez gene - 110084     See in Manteia.
MGI - MGI:107721
RefSeq - XM_017315799
RefSeq - NM_001033668
RefSeq - XM_006518427
RefSeq - XM_017315798
RefSeq - XM_006518426
RefSeq Peptide - NP_001028840
swissprot - E9Q8T7
Ensembl - ENSMUSG00000019027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnah1ENSDARG00000100115Danio rerio
 DNAH1ENSGALG00000004297Gallus gallus
 DNAH1ENSG00000114841Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnah7c / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*ENSMUSG0000010133741
Dnah7a / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*ENSMUSG0000009614141
Dnah3 / Q8BW94 / Dynein heavy chain 3, axonemal ENSMUSG0000005227340
Dnah12ENSMUSG0000002187939
Dnah6 / dynein axonemal heavy chain 6 / Q9C0G6*ENSMUSG0000005286136
Dnah2 / P0C6F1 / Dynein heavy chain 2, axonemal / Q9P225* / dynein axonemal heavy chain 2*ENSMUSG0000000523734
Dnah10ENSMUSG0000003801130
Dnah11 / dynein axonemal heavy chain 11 / Q96DT5*ENSMUSG0000001858129
Dnah17 / dynein axonemal heavy chain 17 / Q9UFH2*ENSMUSG0000003398729
Dnah5 / Q8VHE6 / Dynein heavy chain 5, axonemal ENSMUSG0000002226229
Dnah8 / Q91XQ0 / Dynein heavy chain 8, axonemal / Q96JB1* / dynein axonemal heavy chain 8*ENSMUSG0000003382629
Dnah14 / Q0VDD8* / dynein axonemal heavy chain 14*ENSMUSG0000004736927
Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*ENSMUSG0000001870724


Protein motifs (from Interpro)
Interpro ID Name
 IPR004273  Dynein heavy chain domain
 IPR011704  ATPase, dynein-related, AAA domain
 IPR013602  Dynein heavy chain, domain-2
 IPR024317  Dynein heavy chain, AAA module D4
 IPR024743  Dynein heavy chain, coiled coil stalk
 IPR026975  Dynein heavy chain 1, axonemal
 IPR026983  Dynein heavy chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035699  Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1
 IPR035706  Dynein heavy chain, ATP-binding dynein motor region D5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement IEA
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007288 sperm axoneme assembly IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0036159 inner dynein arm assembly IEA
 biological_processGO:0060294 cilium movement involved in cell motility IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005858 axonemal dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 cellular_componentGO:0036156 inner dynein arm IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IC
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045505 dynein intermediate chain binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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