Manteia - Molecule gene

ENSMUSG00000018581

Mus musculus

Features

Gene ID:	ENSMUSG00000018581

Biological name :	Dnah11

Synonyms :	Dnah11 / dynein axonemal heavy chain 11

Possible biological names infered from orthology :	Q96DT5

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	F2
Gene start:	117877982
Gene end:	118199043

Corresponding Affymetrix probe sets:	10403112 (MoGene1.0st) 1421544_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000081867 Ensembl peptide - ENSMUSP00000135748 NCBI entrez gene - 13411 See in Manteia. MGI - MGI:1100864 RefSeq - XM_017314949 RefSeq - XM_017314946 RefSeq - XM_017314947 RefSeq - XM_017314948 RefSeq - NM_010060 RefSeq - XM_006515463 RefSeq Peptide - NP_034190 swissprot - H3BLD7 swissprot - E9Q7N9 Ensembl - ENSMUSG00000018581

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dnah11	ENSDARG00000094282	Danio rerio
DNAH11	ENSG00000105877	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dnah17 / dynein axonemal heavy chain 17 / Q9UFH2*	ENSMUSG00000033987	57
Dnah2 / P0C6F1 / Dynein heavy chain 2, axonemal / Q9P225* / dynein axonemal heavy chain 2*	ENSMUSG00000005237	30
Dnah10	ENSMUSG00000038011	30
Dnah8 / Q91XQ0 / Dynein heavy chain 8, axonemal / Q96JB1* / dynein axonemal heavy chain 8*	ENSMUSG00000033826	29
Dnah5 / Q8VHE6 / Dynein heavy chain 5, axonemal	ENSMUSG00000022262	29
Dnah1 / E9Q8T7 / Dynein heavy chain 1, axonemal / Q9P2D7* / dynein axonemal heavy chain 1*	ENSMUSG00000019027	28
Dnah6 / dynein axonemal heavy chain 6 / Q9C0G6*	ENSMUSG00000052861	27
Dnah3 / Q8BW94 / Dynein heavy chain 3, axonemal	ENSMUSG00000052273	27
Dnah7a / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*	ENSMUSG00000096141	27
Dnah7c / DNAH7* / Q8WXX0* / dynein axonemal heavy chain 7*	ENSMUSG00000101337	27
Dnah12	ENSMUSG00000021879	27
Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*	ENSMUSG00000018707	25
Dnah14 / Q0VDD8* / dynein axonemal heavy chain 14*	ENSMUSG00000047369	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR003593	AAA+ ATPase domain
IPR004273	Dynein heavy chain domain
IPR011704	ATPase, dynein-related, AAA domain
IPR013594	Dynein heavy chain, domain-1
IPR013602	Dynein heavy chain, domain-2
IPR024317	Dynein heavy chain, AAA module D4
IPR024743	Dynein heavy chain, coiled coil stalk
IPR026983	Dynein heavy chain
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1
IPR035706	Dynein heavy chain, ATP-binding dynein motor region D5

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003341	cilium movement	IMP
biological_process	GO:0003356	regulation of cilium beat frequency	IEA
biological_process	GO:0007018	microtubule-based movement	IEA
biological_process	GO:0007368	determination of left/right symmetry	IEA
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0030317	flagellated sperm motility	IEA
cellular_component	GO:0005930	axoneme	IBA
cellular_component	GO:0030286	dynein complex	IBA
cellular_component	GO:0031514	motile cilium	IMP
molecular_function	GO:0003777	microtubule motor activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	IBA
molecular_function	GO:0016887	ATPase activity	IEA
molecular_function	GO:0045503	dynein light chain binding	IBA
molecular_function	GO:0045505	dynein intermediate chain binding	IBA
molecular_function	GO:0051959	dynein light intermediate chain binding	IBA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob/J
MP:0000276	right ventricle hypertrophy	"increased size of the right ventricle" [J:33629]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Dnaic1^b2b1526Clo/Dnaic1^b2b1526Clo Genetic Background: C57BL/6J-Dnaic1^b2b1526Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0000286	abnormal mitral valve morphology	"malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Dnaic1^b2b1526Clo/Dnaic1^b2b1526Clo Genetic Background: C57BL/6J-Dnaic1^b2b1526Clo
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: a/A^w-22J Genetic Background: C57BL/10Rk
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Apc^tm1Rak/Apc⁺,Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0000531	right pulmonary isomerism	"bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0000542	left-sided isomerism	"the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the left atrium" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0000644	dextrocardia	"cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm3/Dnah11^lrm3 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo Allelic Composition: Dnah11^b2b1468.2Clo/Dnah11^b2b1468.2Clo Genetic Background: C57BL/6J-Dnah11^b2b1468.2Clo
MP:0000650	mesocardia	"cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Abcc2^tm1Ahs/Abcc2^tm1Ahs Genetic Background: FVB.129P2-Abcc2^tm1Ahs
MP:0001727	abnormal embryo implantation	"failure or reduced ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor},Grid2^ho-4J/Grid2^ho-4J Genetic Background: involves: 129S5/SvEvBrd * DBA/2J Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob/J
MP:0001943	abnormal respiration	"anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn,Tg(IghMyc)22Bri/0 Genetic Background: involves: 129S2/SvPas * C57BL * SJL
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adcy1^tm1Drs/Adcy1^tm1Drs,Adcy8^tm1Ljm/Adcy8^tm1Ljm Genetic Background: involves: 129 * Black Swiss
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^tm1Rak/Apc⁺,Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^tm1Bknr/Dnah11^tm1Bknr Genetic Background: involves: 129S1/Sv
MP:0002189	abnormal myocardial trabeculae morphology	"malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnaic1^b2b1526Clo/Dnaic1^b2b1526Clo Genetic Background: C57BL/6J-Dnaic1^b2b1526Clo
MP:0002625	left ventricle hypertrophy	"increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnaic1^b2b1526Clo/Dnaic1^b2b1526Clo Genetic Background: C57BL/6J-Dnaic1^b2b1526Clo
MP:0002766	situs inversus	"lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J Allelic Composition: Dnah11^tm1Bknr/Dnah11^tm1Bknr Genetic Background: involves: 129S1/Sv Allelic Composition: Dnah11^lrm3/Dnah11^lrm3 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Dnah11^b2b1468.2Clo/Dnah11^b2b1468.2Clo Genetic Background: C57BL/6J-Dnah11^b2b1468.2Clo
MP:0003105	abnormal heart atrium morphology	"structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0003178	left pulmonary isomerism	"bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]	Show Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J Allelic Composition: Dnah11^lrm3/Dnah11^lrm3 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0003342	accessory spleen	"the splenic tissue is divided into equal masses; often related to situs inversus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0003649	reduced right ventricle		Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo
MP:0004017	duplex kidney	"a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0004066	abnormal Henson s node morphology	"malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified Allelic Composition: Dnah11^tm1Bknr/Dnah11^tm1Bknr Genetic Background: involves: 129S1/Sv
MP:0004131	abnormal embryonic ciliary morphology	"any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0004133	heterotaxia	"abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo
MP:0004391	abnormal respiratory conducting tube	"any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0004733	abnormal thoracic cavity	"any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0005083	abnormal biliary tract morphology	"anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0006061	right atrial isomerism	"altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0006063	abnormal inferior vena cava morphology	"structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0006128	pulmonary valve stenosis	"abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0008461	left atrial isomerism	"anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0008933	abnormal embryonic cilium physiology	"any functional anomaly of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified Allelic Composition: Dnah11^tm1Bknr/Dnah11^tm1Bknr Genetic Background: involves: 129S1/Sv
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0010404	ostium primum atrial septal defect	"interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0010460	pulmonary artery hypoplasia	"underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715]	Show Allelic Composition: Arntl^tm2Bra/Arntl^tm2Bra,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
MP:0010466	vascular ring	"the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0010489	abnormal heart atrium auricular region morphology	"any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0010607	common atrioventricular valve	"the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0010668	abnormal hepatic portal vein morphology	"any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^iv/Dnah11^iv Genetic Background: SI/Col Tyrp1^b Dnah11^iv/J
MP:0010807	abnormal stomach position or orientation	"the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^lrm3/Dnah11^lrm3 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0010808	right-sided stomach	"stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0010975	abnormal lung lobe morphology	"any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011055	abnormal respiratory motile cilium physiology	"any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0011249	abdominal situs inversus	"lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]	Show Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0011250	abdominal situs ambiguus	"an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011252	situs inversus totalis	"the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]	Show Allelic Composition: Dnah11^b2b598Clo/Dnah11^b2b598Clo Genetic Background: C57BL/6J-Dnah11^b2b598Clo Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011253	situs inversus with levocardia	"situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0011254	superior-inferior ventricles	"an abnormality in which the heart ventricles are in a superior-inferior relationship due to abnormal displacement of the ventricular mass along the horizontal plane of its long axis; this frequently occurs together with criss-cross atrio-ventricular relationships" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011510	biventricular, discordant atrioventricular connection		Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011511	biventricular, ambiguous atrioventricular connection		Show Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011649	immotile respiratory cilia	"failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo Allelic Composition: Dnah11^b2b1468.2Clo/Dnah11^b2b1468.2Clo Genetic Background: C57BL/6J-Dnah11^b2b1468.2Clo
MP:0011665	d-loop transposition of the great arteries	"complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]	Show Allelic Composition: Dnah11^b2b1279Clo/Dnah11^b2b1279Clo Genetic Background: C57BL/6J-Dnah11^b2b1279Clo Allelic Composition: Dnah11^b2b2349Clo/Dnah11^b2b2349Clo Genetic Background: C57BL/6J-Dnah11^b2b2349Clo
MP:0011666	double outlet right ventricle, ventricular defect committed to aorta	"a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]	Show Allelic Composition: Dnah11^b2b1727Clo/Dnah11^b2b1727Clo Genetic Background: C57BL/6J-Dnah11^b2b1727Clo
MP:0011683	dual inferior vena cava	"presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]	Show Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo Genetic Background: C57BL/6J-Dnah11^b2b1203Clo Allelic Composition: Dnah11^b2b1775Clo/Dnah11^b2b1775Clo Genetic Background: C57BL/6J-Dnah11^b2b1775Clo
MP:0011745	isolation of the left subclavian artery	"the loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus" [PMID:16039248]	Show Allelic Composition: Dnah11^b2b1289Clo/Dnah11^b2b1289Clo Genetic Background: C57BL/6J-Dnah11^b2b1289Clo
MP:0012093	absent nodal flow	"absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [MGI:anna]	Show Allelic Composition: Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr