ENSMUSG00000031865


Mus musculus

Features
Gene ID: ENSMUSG00000031865
  
Biological name :Dctn1
  
Synonyms : Dctn1 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / O08788
  
Possible biological names infered from orthology : dynactin subunit 1 / Q14203
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83165920
Gene end: 83200117
  
Corresponding Affymetrix probe sets: 10539364 (MoGene1.0st)   1422521_at (Mouse Genome 430 2.0 Array)   1435414_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109546
Ensembl peptide - ENSMUSP00000109540
Ensembl peptide - ENSMUSP00000109551
Ensembl peptide - ENSMUSP00000121538
Ensembl peptide - ENSMUSP00000115838
Ensembl peptide - ENSMUSP00000109552
Ensembl peptide - ENSMUSP00000076623
NCBI entrez gene - 13191     See in Manteia.
MGI - MGI:107745
RefSeq - XM_017321379
RefSeq - XM_006505488
RefSeq - XM_006505489
RefSeq - XM_006505490
RefSeq - XM_006505491
RefSeq - XM_006505492
RefSeq - XM_006505493
RefSeq - XM_006505494
RefSeq - XM_006505495
RefSeq - XM_006505496
RefSeq - XM_017321378
RefSeq - NM_001198866
RefSeq - NM_001198867
RefSeq - NM_001347310
RefSeq - NM_007835
RefSeq - XM_006505485
RefSeq - XM_006505486
RefSeq - XM_006505487
RefSeq Peptide - NP_001185796
RefSeq Peptide - NP_001334239
RefSeq Peptide - NP_031861
RefSeq Peptide - NP_001185795
swissprot - D3YX34
swissprot - E9Q586
swissprot - O08788
swissprot - E9Q3M3
swissprot - D3Z2M9
swissprot - D3YYG9
Ensembl - ENSMUSG00000031865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dctn1aENSDARG00000019743Danio rerio
 dctn1bENSDARG00000056753Danio rerio
 DCTN1ENSG00000204843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clip1 / Q922J3 / CAP-Gly domain-containing linker protein 1 / P30622*ENSMUSG0000004955017
Cep350 / E9Q309 / Centrosome-associated protein 350 / Q5VT06* / centrosomal protein 350*ENSMUSG0000003367114
Clip2 / Q9Z0H8 / CAP-Gly domain-containing linker protein 2 / Q9UDT6*ENSMUSG0000006314613
Clip4 / Q8CI96 / CAP-Gly domain-containing linker protein 4 / Q8N3C7* / CAP-Gly domain containing linker protein family member 4*ENSMUSG000000240595
Clip3 / B9EHT4 / CAP-Gly domain-containing linker protein 3 / AC006030.1*ENSMUSG000000139214
Tbcb / Q9D1E6 / Tubulin-folding cofactor B / Q99426*ENSMUSG000000060952


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR022157  Dynein associated protein
 IPR027663  Dynactin subunit 1
 IPR036859  CAP Gly-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010457 centriole-centriole cohesion ISS
 biological_processGO:0010970 transport along microtubule IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization ISO
 biological_processGO:0031122 cytoplasmic microtubule organization ISS
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0034454 microtubule anchoring at centrosome ISS
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:0051081 nuclear envelope disassembly ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060236 regulation of mitotic spindle organization ISS
 biological_processGO:0090063 positive regulation of microtubule nucleation ISO
 biological_processGO:0090316 positive regulation of intracellular protein transport ISS
 biological_processGO:1905515 non-motile cilium assembly ISS
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005869 dynactin complex IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0030904 retromer complex ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0035371 microtubule plus-end ISO
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 cellular_componentGO:0099738 cell cortex region ISO
 cellular_componentGO:0120103 centriolar subdistal appendage ISO
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0015631 tubulin binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dctn1tm1.1Cai/Dctn1tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dctn1tm1.1Cai/Dctn1tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dctn1tm1.1Cai/Dctn1tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Reltm1Grd/Rel+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dctn1tm1.1Cai/Dctn1tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / complex
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / complex / reaction
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / complex / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / complex / reaction
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr