ENSMUSG00000063146


Mus musculus

Features
Gene ID: ENSMUSG00000063146
  
Biological name :Clip2
  
Synonyms : CAP-Gly domain-containing linker protein 2 / Clip2 / Q9Z0H8
  
Possible biological names infered from orthology : Q9UDT6
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134489383
Gene end: 134552434
  
Corresponding Affymetrix probe sets: 10534281 (MoGene1.0st)   1422984_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037431
Ensembl peptide - ENSMUSP00000098212
NCBI entrez gene - 269713     See in Manteia.
MGI - MGI:1313136
RefSeq - XM_006504427
RefSeq - NM_001039162
RefSeq - NM_009990
RefSeq Peptide - NP_034120
RefSeq Peptide - NP_001034251
swissprot - Q9Z0H8
Ensembl - ENSMUSG00000063146
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clip2ENSDARG00000059596Danio rerio
 CLIP2ENSGALG00000030450Gallus gallus
 CLIP2ENSG00000106665Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clip1 / Q922J3 / CAP-Gly domain-containing linker protein 1 / P30622*ENSMUSG0000004955042
Cep350 / E9Q309 / Centrosome-associated protein 350 / Q5VT06* / centrosomal protein 350*ENSMUSG0000003367120
Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*ENSMUSG0000003186516
Clip4 / Q8CI96 / CAP-Gly domain-containing linker protein 4 / Q8N3C7* / CAP-Gly domain containing linker protein family member 4*ENSMUSG0000002405913
Clip3 / B9EHT4 / CAP-Gly domain-containing linker protein 3 / AC006030.1*ENSMUSG000000139219
Tbcb / Q9D1E6 / Tubulin-folding cofactor B / Q99426*ENSMUSG000000060956


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR028394  CAP-Gly domain-containing linker protein 2
 IPR036859  CAP Gly-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0035371 microtubule plus-end IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0051010 microtubule plus-end binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Clip2tm1.1Gal/Clip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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