ENSMUSG00000049550


Mus musculus

Features
Gene ID: ENSMUSG00000049550
  
Biological name :Clip1
  
Synonyms : CAP-Gly domain-containing linker protein 1 / Clip1 / Q922J3
  
Possible biological names infered from orthology : P30622
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 123577795
Gene end: 123684618
  
Corresponding Affymetrix probe sets: 10533659 (MoGene1.0st)   1425060_s_at (Mouse Genome 430 2.0 Array)   1431098_at (Mouse Genome 430 2.0 Array)   1439800_at (Mouse Genome 430 2.0 Array)   1450351_a_at (Mouse Genome 430 2.0 Array)   1452929_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121425
Ensembl peptide - ENSMUSP00000119641
Ensembl peptide - ENSMUSP00000122064
Ensembl peptide - ENSMUSP00000031382
Ensembl peptide - ENSMUSP00000068241
Ensembl peptide - ENSMUSP00000107186
Ensembl peptide - ENSMUSP00000107190
Ensembl peptide - ENSMUSP00000107192
Ensembl peptide - ENSMUSP00000115965
NCBI entrez gene - 56430     See in Manteia.
MGI - MGI:1928401
RefSeq - XM_017321032
RefSeq - XM_017321020
RefSeq - XM_017321022
RefSeq - XM_017321023
RefSeq - XM_017321024
RefSeq - XM_017321025
RefSeq - XM_017321026
RefSeq - XM_017321027
RefSeq - XM_017321028
RefSeq - XM_017321029
RefSeq - XM_017321030
RefSeq - XM_017321031
RefSeq - NM_001291229
RefSeq - NM_019765
RefSeq - XM_006530407
RefSeq - XM_006530409
RefSeq - XM_006530410
RefSeq - XM_006530411
RefSeq - XM_006530412
RefSeq - XM_006530413
RefSeq - XM_006530414
RefSeq - XM_006530415
RefSeq - XM_006530416
RefSeq - XM_006530417
RefSeq - XM_006530418
RefSeq - XM_006530419
RefSeq - XM_006530420
RefSeq - XM_006530421
RefSeq - XM_006530422
RefSeq - XM_006530423
RefSeq - XM_006530424
RefSeq - XM_011248233
RefSeq - XM_011248234
RefSeq - XM_017321017
RefSeq - XM_017321019
RefSeq Peptide - NP_001334397
RefSeq Peptide - NP_062739
RefSeq Peptide - NP_001278158
swissprot - F8WIA1
swissprot - D3Z3M7
swissprot - Q922J3
swissprot - D3Z2Z1
swissprot - F6RAY2
swissprot - Q8C0S5
swissprot - F6RCU2
swissprot - F7CB97
Ensembl - ENSMUSG00000049550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbcbENSDARG00000068404Danio rerio
 CLIP1ENSGALG00000004467Gallus gallus
 CLIP1ENSG00000130779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clip2 / Q9Z0H8 / CAP-Gly domain-containing linker protein 2 / Q9UDT6*ENSMUSG0000006314632
Cep350 / E9Q309 / Centrosome-associated protein 350 / Q5VT06* / centrosomal protein 350*ENSMUSG0000003367118
Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*ENSMUSG0000003186516
Clip4 / Q8CI96 / CAP-Gly domain-containing linker protein 4 / Q8N3C7* / CAP-Gly domain containing linker protein family member 4*ENSMUSG0000002405910
Clip3 / B9EHT4 / CAP-Gly domain-containing linker protein 3 / AC006030.1*ENSMUSG000000139217
Tbcb / Q9D1E6 / Tubulin-folding cofactor B / Q99426*ENSMUSG000000060955


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR032108  CLIP1, zinc knuckle
 IPR036859  CAP Gly-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0044861 protein transport into plasma membrane raft IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051010 microtubule plus-end binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009377 ectopic manchette "abnormal position of the conic array of microtubules that normally invests the posterior nucleus of a spermatid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clip1tm1Gal/Clip1tm1Gal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / reaction / complex






 

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