ENSG00000130779


Homo sapiens

Features
Gene ID: ENSG00000130779
  
Biological name :CLIP1
  
Synonyms : CAP-Gly domain containing linker protein 1 / CLIP1 / P30622
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 122271432
Gene end: 122422632
  
Corresponding Affymetrix probe sets: 1557512_at (Human Genome U133 Plus 2.0 Array)   1558924_s_at (Human Genome U133 Plus 2.0 Array)   1568012_at (Human Genome U133 Plus 2.0 Array)   201975_at (Human Genome U133 Plus 2.0 Array)   210716_s_at (Human Genome U133 Plus 2.0 Array)   240444_x_at (Human Genome U133 Plus 2.0 Array)   242287_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446379
Ensembl peptide - ENSP00000445531
Ensembl peptide - ENSP00000479322
Ensembl peptide - ENSP00000303585
Ensembl peptide - ENSP00000351665
Ensembl peptide - ENSP00000355314
Ensembl peptide - ENSP00000437617
Ensembl peptide - ENSP00000437786
Ensembl peptide - ENSP00000438743
Ensembl peptide - ENSP00000439093
Ensembl peptide - ENSP00000439472
Ensembl peptide - ENSP00000441409
Ensembl peptide - ENSP00000445387
NCBI entrez gene - 6249     See in Manteia.
OMIM - 179838
RefSeq - XM_017019792
RefSeq - NM_001247997
RefSeq - NM_002956
RefSeq - NM_198240
RefSeq - XM_005253593
RefSeq - XM_006719552
RefSeq - XM_017019786
RefSeq - XM_017019787
RefSeq - XM_017019788
RefSeq - XM_017019789
RefSeq - XM_017019790
RefSeq - XM_017019791
RefSeq Peptide - NP_937883
RefSeq Peptide - NP_002947
RefSeq Peptide - NP_001234926
swissprot - F5H270
swissprot - F5H367
swissprot - F5H6A0
swissprot - F5H6H4
swissprot - F6VGP8
swissprot - J3KP58
swissprot - P30622
swissprot - A0A024RBR1
swissprot - F5H0N7
swissprot - F5H1T5
Ensembl - ENSG00000130779
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbcbENSDARG00000068404Danio rerio
 CLIP1ENSGALG00000004467Gallus gallus
 Clip1ENSMUSG00000049550Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLIP2 / Q9UDT6 / CAP-Gly domain containing linker protein 2ENSG0000010666533
CEP350 / Q5VT06 / centrosomal protein 350ENSG0000013583720
DCTN1 / Q14203 / dynactin subunit 1ENSG0000020484316
CLIP4 / Q8N3C7 / CAP-Gly domain containing linker protein family member 4ENSG0000011529511
CLIP3 / Q96DZ5 / CAP-Gly domain containing linker protein 3ENSG000001052707
TBCB / Q99426 / tubulin folding cofactor BENSG000001052545
AC006030.1ENSG000002643241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR032108  CLIP1, zinc knuckle
 IPR036859  CAP Gly-rich domain superfamily
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0001578 microtubule bundle formation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0044861 protein transport into plasma membrane raft IEA
 cellular_componentGO:0000776 kinetochore TAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IMP
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005882 intermediate filament TAS
 cellular_componentGO:0015630 microtubule cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044354 macropinosome IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding TAS
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0046872 metal ion binding NAS
 molecular_functionGO:0051010 microtubule plus-end binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex






 

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