Manteia

ENSMUSG00000030536

Mus musculus

Features

Gene ID:	ENSMUSG00000030536

Biological name :	Iqgap1

Synonyms :	Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1

Possible biological names infered from orthology :	IQ motif containing GTPase activating protein 1 / P46940

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	D3
Gene start:	80711583
Gene end:	80825974

Corresponding Affymetrix probe sets:	10565018 (MoGene1.0st) 1417379_at (Mouse Genome 430 2.0 Array) 1417380_at (Mouse Genome 430 2.0 Array) 1431395_a_at (Mouse Genome 430 2.0 Array) 1431396_at (Mouse Genome 430 2.0 Array) 1434998_at (Mouse Genome 430 2.0 Array) 1445724_at (Mouse Genome 430 2.0 Array) 1458124_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000128278 Ensembl peptide - ENSMUSP00000146126 Ensembl peptide - ENSMUSP00000145991 Ensembl peptide - ENSMUSP00000145556 NCBI entrez gene - 29875 See in Manteia. MGI - MGI:1352757 RefSeq - XM_006540950 RefSeq - NM_016721 RefSeq Peptide - NP_057930 swissprot - A0A0U1RPI2 swissprot - A0A0U1RPU3 swissprot - Q9JKF1 swissprot - A0A0U1RNG5 Ensembl - ENSMUSG00000030536

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
iqgap1	ENSDARG00000078888	Danio rerio
IQGAP1	ENSGALG00000030162	Gallus gallus
IQGAP1	ENSG00000140575	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*	ENSMUSG00000021676	57
Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*	ENSMUSG00000028068	56

Protein motifs (from Interpro)

Interpro ID	Name
IPR000048	IQ motif, EF-hand binding site
IPR000593	RasGAP protein, C-terminal
IPR001202	WW domain
IPR001715	Calponin homology domain
IPR001936	Ras GTPase-activating domain
IPR008936	Rho GTPase activation protein
IPR023152	Ras GTPase-activating protein, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR036872	CH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001817	regulation of cytokine production	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP
biological_process	GO:0007346	regulation of mitotic cell cycle	IEA
biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP
biological_process	GO:0035305	negative regulation of dephosphorylation	IGI
biological_process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IMP
biological_process	GO:0043087	regulation of GTPase activity	IEA
biological_process	GO:0043406	positive regulation of MAP kinase activity	IEA
biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	IMP
biological_process	GO:0045860	positive regulation of protein kinase activity	IEA
biological_process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP
biological_process	GO:0051894	positive regulation of focal adhesion assembly	IEA
biological_process	GO:0071277	cellular response to calcium ion	IEA
biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	IEA
biological_process	GO:0072015	glomerular visceral epithelial cell development	ISS
biological_process	GO:1900006	positive regulation of dendrite development	IEA
biological_process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	IEA
biological_process	GO:1903829	positive regulation of cellular protein localization	IEA
biological_process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	IEA
biological_process	GO:1990138	neuron projection extension	IEA
biological_process	GO:1990776	response to angiotensin	IEA
cellular_component	GO:0001726	ruffle	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0005911	cell-cell junction	IDA
cellular_component	GO:0005925	focal adhesion	IEA
cellular_component	GO:0015629	actin cytoskeleton	IEA
cellular_component	GO:0015630	microtubule cytoskeleton	IEA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016328	lateral plasma membrane	IDA
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0030426	growth cone	IEA
cellular_component	GO:0030496	midbody	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA
cellular_component	GO:0031252	cell leading edge	IGI
cellular_component	GO:0036057	slit diaphragm	ISS
cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	IEA
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:0045121	membrane raft	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005516	calmodulin binding	ISO
molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IEA
molecular_function	GO:0017048	Rho GTPase binding	IPI
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0019903	protein phosphatase binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0043539	protein serine/threonine kinase activator activity	IEA
molecular_function	GO:0044548	S100 protein binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0048365	Rac GTPase binding	IPI
molecular_function	GO:0051019	mitogen-activated protein kinase binding	IEA

Pathways (from Reactome)

Pathway description

Nephrin family interactions

RHO GTPases activate IQGAPs

MAP2K and MAPK activation

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003331	hepatocellular carcinoma	"malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Iqgap1^tm1Aber/Iqgap1^tm1Aber,Iqgap2^tm1Vs/Iqgap2^tm1Vs Genetic Background: involves: 129S4/SvJae
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Iqgap1^tm1Aber/Iqgap1^tm1Aber,Iqgap2^tm1Vs/Iqgap2^tm1Vs Genetic Background: involves: 129S4/SvJae
MP:0005210	disorganized gastric mucosa	"disorderly structure of the stomach epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]	Show Allelic Composition: Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio Genetic Background: involves: 129S2/SvPas
MP:0010792	abnormal stomach mucosa morphology	"any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio Genetic Background: involves: 129S2/SvPas

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000303	Cdh1 / cadherin 1 / P12830*	/ reaction / complex
ENSMUSG00000006649	Nphs1 / Q9QZS7 / Nephrin / O60500* / NPHS1, nephrin*	/ complex / reaction
ENSMUSG00000006932	Ctnnb1 / Q02248 / Catenin beta-1 / P35222*	/ complex / reaction
ENSMUSG00000041734	Q80W68 / Kirrel / Kin of IRRE-like protein 1 / Q96J84* / KIRREL1* / kirre like nephrin family adhesion molecule 1*	/ reaction / complex
ENSMUSG00000037815	Ctnna1 / P26231 / Catenin alpha-1 / P35221*	/ complex / reaction
ENSMUSG00000049550	Clip1 / Q922J3 / CAP-Gly domain-containing linker protein 1 / P30622*	/ reaction / complex
ENSMUSG00000024947	Men1 / Menin / O88559 / O00255* / menin 1*	/ complex / reaction
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ complex / reaction
ENSMUSG00000001175	Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*	/ reaction / complex
ENSMUSG00000029580	Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*	/ complex / reaction
ENSMUSG00000030536	Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*	/ complex
ENSMUSG00000062825	Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr