ENSGALG00000030162


Gallus gallus

Features
Gene ID: ENSGALG00000030162
  
Biological name :IQGAP1
  
Synonyms : IQGAP1 / IQ motif containing GTPase activating protein 1
  
Possible biological names infered from orthology : P46940 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 20331935
Gene end: 20379943
  
Corresponding Affymetrix probe sets: Gga.2251.1.S1_at (Chicken Array)   GgaAffx.22641.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052786
NCBI entrez gene - 415591     See in Manteia.
RefSeq - XM_413959
swissprot - A0A1D5PIZ8
Ensembl - ENSGALG00000030162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap1ENSDARG00000078888Danio rerio
 IQGAP1ENSG00000140575Homo sapiens
 Iqgap1ENSMUSG00000030536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IQGAP2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *ENSGALG0000001497864


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR027401  Myosin IQ motif-containing domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0035305 negative regulation of dephosphorylation IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009621 ACTB / P60706 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60709* / P60710* / actin beta*  / reaction / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / reaction / complex
 ENSGALG00000030162 IQGAP1 / IQ motif containing GTPase activating protein 1 / P46940* / Q9JKF1* / Ras GTPase-activating-like protein IQGAP1 *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction






 

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