ENSGALG00000014978


Gallus gallus

Features
Gene ID: ENSGALG00000014978
  
Biological name :IQGAP2
  
Synonyms : IQGAP2 / IQ motif containing GTPase activating protein 2
  
Possible biological names infered from orthology : Q13576 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 23461599
Gene end: 23577675
  
Corresponding Affymetrix probe sets: Gga.10949.1.S1_at (Chicken Array)   Gga.14355.1.S1_at (Chicken Array)   Gga.16940.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024116
Ensembl peptide - ENSGALP00000054755
Ensembl peptide - ENSGALP00000046997
NCBI entrez gene - 427211     See in Manteia.
RefSeq - XM_015277326
RefSeq - XM_015277322
RefSeq - XM_015277323
RefSeq - XM_015277324
RefSeq - XM_015277325
RefSeq - NM_001277778
RefSeq - XM_015277320
RefSeq - XM_015277321
RefSeq Peptide - NP_001264707
swissprot - E1C2F9
swissprot - A0A1D5PPF6
swissprot - A0A1D5P2U7
Ensembl - ENSGALG00000014978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap2ENSDARG00000060010Danio rerio
 IQGAP2ENSG00000145703Homo sapiens
 Iqgap2ENSMUSG00000021676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IQGAP1 / IQ motif containing GTPase activating protein 1 / P46940* / Q9JKF1* / Ras GTPase-activating-like protein IQGAP1 *ENSGALG0000003016264


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031941 filamentous actin IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0071933 Arp2/3 complex binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000009621 ACTB / P60706 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60709* / P60710* / actin beta*  / reaction / complex
 ENSGALG00000014978 IQGAP2 / IQ motif containing GTPase activating protein 2 / Q13576* / Q3UQ44* / Ras GTPase-activating-like protein IQGAP2 *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / reaction / complex






 

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