ENSMUSG00000024947


Mus musculus

Features
Gene ID: ENSMUSG00000024947
  
Biological name :Men1
  
Synonyms : Men1 / Menin / O88559
  
Possible biological names infered from orthology : menin 1 / O00255
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6334979
Gene end: 6340891
  
Corresponding Affymetrix probe sets: 10460879 (MoGene1.0st)   1416347_at (Mouse Genome 430 2.0 Array)   1416348_at (Mouse Genome 430 2.0 Array)   1443826_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109132
Ensembl peptide - ENSMUSP00000133085
Ensembl peptide - ENSMUSP00000128607
Ensembl peptide - ENSMUSP00000126655
Ensembl peptide - ENSMUSP00000058149
Ensembl peptide - ENSMUSP00000077272
Ensembl peptide - ENSMUSP00000078306
Ensembl peptide - ENSMUSP00000109128
Ensembl peptide - ENSMUSP00000109129
Ensembl peptide - ENSMUSP00000109130
Ensembl peptide - ENSMUSP00000109131
NCBI entrez gene - 17283     See in Manteia.
MGI - MGI:1316736
RefSeq - NM_008583
RefSeq - NM_001168490
RefSeq - NM_001168488
RefSeq - NM_001168489
RefSeq Peptide - NP_032609
RefSeq Peptide - NP_001161960
RefSeq Peptide - NP_001161961
RefSeq Peptide - NP_001161962
swissprot - O88559
swissprot - D3YZC2
swissprot - A0A0R4J1I3
swissprot - F6ZTV9
swissprot - F7CJP6
swissprot - F8WHD9
swissprot - E9PV51
Ensembl - ENSMUSG00000024947
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 men1ENSDARG00000089456Danio rerio
 MEN1ENSG00000133895Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007747  Menin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001776 leukocyte homeostasis IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002051 osteoblast fate commitment IGI
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031062 positive regulation of histone methylation IMP
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032925 regulation of activin receptor signaling pathway IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046621 negative regulation of organ growth IDA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051781 positive regulation of cell division IMP
 biological_processGO:0051974 negative regulation of telomerase activity IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IDA
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0071559 response to transforming growth factor beta IEA
 biological_processGO:1902807 negative regulation of cell cycle G1/S phase transition IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000403 Y-form DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Deactivation of the beta-catenin transactivating complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate IQGAPs
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Men1tm1Mmey/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

 MP:0000636 enlarged pituitary gland "increased size of pituitary gland" [J:50053]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm1Ctre/Men1+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Kdm5atm1Kael/Kdm5atm1Kael,Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax64Neu/Pax6+
Genetic Background: either: (involves: 102 * C3H) or (involves: C3H)

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

 MP:0003112 enlarged parathyroid gland 
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0003364 insulinoma "a pancreatic islet beta cell adenoma that secretes excess insulin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Gfk/Men1tm1Gfk,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Kdm5atm1Kael/Kdm5atm1Kael,Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

 MP:0003365 glucagonoma "a pancreatic islet alpha cell adenoma that secretes excess glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0003430 islet cell adenoma "a benign epithelial neoplasm with a glandular organization present in islet cells of the pancreas" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0003493 parathyroid hyperplasia 
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0003495 parathyroid ademona "appearance of benign neoplasms in the parathyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0003498 thyroid hyperplasia 
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0003505 prolactinoma "a pituitary adenoma characterized by secretion of prolactin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Gfk/Men1tm1Gfk,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Men1tm1Mmey/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Men1tm1Zqw/Men1tm1Zqw
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Kdm5atm1Kael/Kdm5atm1Kael,Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Gfk/Men1tm1Gfk,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Kdm5atm1Kael/Kdm5atm1Kael,Men1tm2.1Mmey/Men1tm2.1Mmey,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1.2Ctre/Men1tm1.2Ctre,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0009043 pancreas adenoma "a benign epithelial neoplasm located in the pancreas" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

 MP:0009044 adrenal gland adenoma "a benign epithelial neoplasm located in the adrenal gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0009148 pancreas necrosis "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Gfk/Men1tm1Gfk,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Men1tm1Ctre/Men1tm1Ctre,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0009590 gonad tumor "presence of abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0009592 Leydig cell tumor "rare testicular tumors of the male gonadal interstitium that are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Men1tm2.1Gfk/Men1+
Genetic Background: involves: 129T2/SvEms * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010288 increased gland tumor incidence "greater than the expected number of tumors originating in a gland in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0010321 increased parathyroid gland tumor incidence "greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0010345 increased thyroid C-cell carcinoma incidence "greater than the expected number of a malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland, occurring in a specific population in a given time period" [MPATH:308]
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0010346 increased thyroid carcinioma incidence "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010348 increased pancreatic islet cell carcinoma incidence "greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010350 increased pituitary adenohypophysis tumor incidence "greater than the expected number of neoplasms in the anterior part of the pituitary that secretes a variety of hormones, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0010351 increased pituitary melanotroph tumor incidence "greater than the expected number of neoplasms derived from the cells of intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1.1Ctre/Men1+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0010366 increased adrenal cortical tumor incidence "greater than the expected number of neoplams in the adrenal cortex occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Men1tm1Rvt/Men1+
Genetic Background: involves: 129 * C57BL/6

 MP:0010390 increased adrenocortical adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the adrenal cortex, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Men1tm1Zqw/Men1tm1Zqw
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1tm1.1Ctre
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Men1tm1Rvt/Men1tm1Rvt
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

Allelic Composition: Men1tm1.1Ctre/Men1tm1.1Ctre
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

Allelic Composition: Men1tm1Ctre/Men1tm1Ctre
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Men1tm1Zqw/Men1tm1Zqw
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0013528 thyroid cyst "presence of fluid-filled cavities (cysts) in the thyroid most commonly resulting from degenerating thyroid adenomas; often, solid components are mixed with fluid in thyroid cysts; thyroid cysts are usually benign, but they occasionally contain malignant solid components" [http://www.mayoclinic.org/diseases-conditions/thyroid-nodules/basics/causes/con-20021546, MGI:Anna]
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Allelic Composition: Men1tm1Ctre/Men1+
Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / complex / reaction
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex






 

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