ENSMUSG00000032402


Mus musculus

Features
Gene ID: ENSMUSG00000032402
  
Biological name :Smad3
  
Synonyms : Mothers against decapentaplegic homolog 3 / Q8BUN5 / Smad3
  
Possible biological names infered from orthology : P84022 / SMAD family member 3
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 63646767
Gene end: 63757994
  
Corresponding Affymetrix probe sets: 10594404 (MoGene1.0st)   1450471_at (Mouse Genome 430 2.0 Array)   1450472_s_at (Mouse Genome 430 2.0 Array)   1454960_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122217
Ensembl peptide - ENSMUSP00000034973
Ensembl peptide - ENSMUSP00000116790
Ensembl peptide - ENSMUSP00000121671
NCBI entrez gene - 17127     See in Manteia.
MGI - MGI:1201674
RefSeq - XM_006510821
RefSeq - NM_016769
RefSeq - XM_006510819
RefSeq Peptide - NP_058049
swissprot - A2CG44
swissprot - Q8BUN5
swissprot - F7BUP2
swissprot - A2CG45
Ensembl - ENSMUSG00000032402
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad3aENSDARG00000036096Danio rerio
 smad3bENSDARG00000010207Danio rerio
 SMAD3ENSGALG00000035701Gallus gallus
 SMAD3ENSG00000166949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*ENSMUSG0000002456392
Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*ENSMUSG0000002154067
Smad1 / P70340 / SMAD family member 1 / Q15797*ENSMUSG0000003168166
Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*ENSMUSG0000002779663
Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*ENSMUSG0000002451543
Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*ENSMUSG0000003686726
Smad7 / O35253 / SMAD family member 7 / O15105*ENSMUSG0000002588025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily
 IPR036578  SMAD MH1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IGI
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0002076 osteoblast development IGI
 biological_processGO:0002520 immune system development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007183 SMAD protein complex assembly IEA
 biological_processGO:0007369 gastrulation IGI
 biological_processGO:0007492 endoderm development IGI
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009880 embryonic pattern specification IGI
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016202 regulation of striated muscle tissue development IDA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0019049 evasion or tolerance of host defenses by virus IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IMP
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IEA
 biological_processGO:0032916 positive regulation of transforming growth factor beta3 production IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0038092 nodal signaling pathway IEA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048340 paraxial mesoderm morphogenesis IMP
 biological_processGO:0048589 developmental growth IGI
 biological_processGO:0048617 embryonic foregut morphogenesis IGI
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051098 regulation of binding IDA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060039 pericardium development IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060290 transdifferentiation IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISO
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0061045 negative regulation of wound healing IMP
 biological_processGO:0061767 negative regulation of lung blood pressure IEA
 biological_processGO:0070306 lens fiber cell differentiation IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0071141 SMAD protein complex IEA
 cellular_componentGO:0071144 heteromeric SMAD protein complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031962 mineralocorticoid receptor binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:0070878 primary miRNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt19tm1Alki/Krt19+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inhbatm1Zuk/Inhba+,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000997 abnormal joint capsule morphology "anomalous structure of the sac that encloses the articulating ends of bones participating in a synovial joint " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001272 increased metastatic potential 
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt19tm1Alki/Krt19+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt19tm1Alki/Krt19+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3tm1Par
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nogtm1Amc/Nog+,Smad3tm1Xfw/Smad3+
Genetic Background: involves: 129/Sv * 129S1/Sv

Allelic Composition: Nogtm1Amc/Nog+,Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * 129S1/Sv

Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt19tm1Alki/Krt19+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003200 joint calcification "pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rab25tm1Jrgo/Rab25tm1Jrgo,Smad3tm1Par/Smad3+
Genetic Background: 129-Rab25tm1Jrgo Smad3tm1Par

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004199 enlarged fetal size "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004387 abnormal prechordal plate morphology "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3+
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

 MP:0004967 abnormal kidney epithelium morphology "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005109 abnormal talus morphology "malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3+
Genetic Background: involves: 129/Sv * 129S1/Sv

Allelic Composition: Nogtm1Amc/Nog+,Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * 129S1/Sv

Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3tm1Par
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

Allelic Composition: Inhatm1Bay/Inhatm1Bay,Smad3tm1Par/Smad3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBr * 129X1/Sv * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nefhtm1Ral/Nefhtm1Ral,Nefmtm1Ral/Nefmtm1Ral
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008595 abnormal circulating interleukin-6 level "anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Smad3tm1Par/Smad3tm1Par
Genetic Background: 129-Smad3tm1Par/J

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

Allelic Composition: Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3+
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc,Smad3tm1Xfw/Smad3+
Genetic Background: involves: 129/Sv * 129S1/Sv

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab25tm1Jrgo/Rab25tm1Jrgo,Smad3tm1Par/Smad3+
Genetic Background: 129-Rab25tm1Jrgo Smad3tm1Par

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009373 abnormal cumulus expansion "defective or reduced ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Gper1tm1.1Lmlf/Gper1tm1.1Lmlf
Genetic Background: B6.129-Gper1tm1.1Lmlf

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011338 abnormal mesangial matrix morphology "any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

 MP:0011349 abnormal renal glomerulus basement membrane thickness "increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Smad3tm1Sche/Smad3tm1Sche
Genetic Background: B6.129P2-Smad3tm1Sche

 MP:0011372 decreased renal tubule apoptosis "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012245 abnormal hepatoblast migration "atypical migration of hepatoblasts across the basement membrane of the liver bud and/or invasion of the neighboring septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / reaction
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / complex / reaction
 ENSMUSG00000011960 Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*  / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000021096 Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*  / reaction / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000026349 Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*  / reaction
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / reaction
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction / complex
 ENSMUSG00000034557 Zfyve9 / zinc finger, FYVE domain containing 9 / O95405* / zinc finger FYVE-type containing 9*  / reaction
 ENSMUSG00000029635 Cdk8 / Q8R3L8 / Cyclin-dependent kinase 8 / P49336*  / reaction
 ENSMUSG00000029478 Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*  / reaction / complex
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / reaction
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / reaction
 ENSMUSG00000039615 Stub1 / Q9WUD1 / STIP1 homology and U-Box containing protein 1 / Q9UNE7*  / complex / reaction
 ENSMUSG00000018401 Mtmr4 / Q91XS1 / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA. / Q9NYA4* / myotubularin related protein 4*  / reaction / complex
 ENSMUSG00000029050 Ski / SKI proto-oncogene / P12755*  / reaction / complex
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000001280 Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*  / reaction / complex
 ENSMUSG00000027660 Skil / Q60665 / SKI-like / P12757* / SKI like proto-oncogene*  / reaction / complex
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction
 ENSMUSG00000038400 Pmepa1 / prostate transmembrane protein, androgen induced 1 / Q969W9*  / reaction / complex
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction / complex
 ENSMUSG00000033837 Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*  / complex / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex / reaction
 ENSMUSG00000024947 Men1 / Menin / O88559 / O00255* / menin 1*  / reaction / complex
 ENSMUSG00000048756 Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*  / complex / reaction
 ENSMUSG00000028252 Ccnc / Q62447 / Cyclin-C / P24863*  / reaction
 ENSMUSG00000047407 Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*  / reaction / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000062175 Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*  / reaction / complex
 ENSMUSG00000021258 Ccnk / cyclin K / O75909*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction






 

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