ENSMUSG00000011960


Mus musculus

Features
Gene ID: ENSMUSG00000011960
  
Biological name :Ccnt1
  
Synonyms : Ccnt1 / Cyclin-T1 / Q9QWV9
  
Possible biological names infered from orthology : O60563
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98538689
Gene end: 98570923
  
Corresponding Affymetrix probe sets: 10432180 (MoGene1.0st)   1419313_at (Mouse Genome 430 2.0 Array)   1456477_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126874
Ensembl peptide - ENSMUSP00000130286
Ensembl peptide - ENSMUSP00000012104
NCBI entrez gene - 12455     See in Manteia.
MGI - MGI:1328363
RefSeq - NM_009833
RefSeq Peptide - NP_033963
swissprot - E9Q7A7
swissprot - Q9QWV9
Ensembl - ENSMUSG00000011960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnt1ENSDARG00000017525Danio rerio
 CCNT1ENSG00000129315Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*ENSMUSG0000002634947
Ccnk / cyclin K / O75909*ENSMUSG0000002125819
Ccnl2 / Q9JJA7 / Cyclin-L2 / Q96S94*ENSMUSG0000002906816
Ccnl1 / Q52KE7 / Mus musculus cyclin L1 (Ccnl1), transcript variant 2, mRNA. / Q9UK58* / cyclin L1*ENSMUSG0000002782915
Ccnc / Q62447 / Cyclin-C / P24863*ENSMUSG000000282529
Fam58b / Q8QZR8 / family with sequence similarity 58, member B / CCNQ* / Q8N1B3* / cyclin Q*ENSMUSG000000494896


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028863  Cyclin-T1
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation ISO
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex TAS
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA
 molecular_functionGO:0017069 snRNA binding IDA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0070063 RNA polymerase binding ISO
 molecular_functionGO:0097322 7SK snRNA binding ISO


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / complex
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / complex






 

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