ENSMUSG00000009555


Mus musculus

Features
Gene ID: ENSMUSG00000009555
  
Biological name :Cdk9
  
Synonyms : Cdk9 / Cyclin-dependent kinase 9 / Q99J95
  
Possible biological names infered from orthology : P50750
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32705784
Gene end: 32713076
  
Corresponding Affymetrix probe sets: 10481670 (MoGene1.0st)   1417269_at (Mouse Genome 430 2.0 Array)   1457240_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113327
Ensembl peptide - ENSMUSP00000120857
Ensembl peptide - ENSMUSP00000115318
Ensembl peptide - ENSMUSP00000115299
Ensembl peptide - ENSMUSP00000009699
NCBI entrez gene - 107951     See in Manteia.
MGI - MGI:1328368
RefSeq - XM_011239001
RefSeq - NM_130860
RefSeq Peptide - NP_570930
swissprot - D6RGN3
swissprot - D6RHP4
swissprot - Q99J95
swissprot - B0R021
Ensembl - ENSMUSG00000009555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk9ENSDARG00000044811Danio rerio
 CDK9ENSGALG00000035576Gallus gallus
 CDK9ENSG00000136807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk12 / Q14AX6 / Cyclin-dependent kinase 12 / Q9NYV4*ENSMUSG0000000311932
Cdk13 / Q69ZA1 / Cyclin-dependent kinase 13 / Q14004*ENSMUSG0000004129731


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006282 regulation of DNA repair ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031056 regulation of histone modification ISO
 biological_processGO:0031297 replication fork processing ISO
 biological_processGO:0033129 positive regulation of histone phosphorylation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051147 regulation of muscle cell differentiation ISO
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IBA
 biological_processGO:0071157 negative regulation of cell cycle arrest ISO
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:1900364 negative regulation of mRNA polyadenylation ISO
 biological_processGO:1903839 positive regulation of mRNA 3"-UTR binding ISO
 biological_processGO:2001168 positive regulation of histone H2B ubiquitination IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex ISO
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex TAS
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001223 transcription coactivator binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017069 snRNA binding IDA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0030332 cyclin binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0097322 7SK snRNA binding ISO


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction
 ENSMUSG00000026349 Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction
 ENSMUSG00000011960 Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*  / complex / reaction
 ENSMUSG00000021258 Ccnk / cyclin K / O75909*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / complex






 

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