ENSDARG00000044811


Danio rerio

Features
Gene ID: ENSDARG00000044811
  
Biological name :cdk9
  
Synonyms : cdk9 / cyclin-dependent kinase 9 (CDC2-related kinase)
  
Possible biological names infered from orthology : cyclin dependent kinase 9 / P50750 / Q99J95
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 6136981
Gene end: 6150568
  
Corresponding Affymetrix probe sets: Dr.26326.1.S1_at (Zebrafish Array)   NM_212591_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000134607
Ensembl peptide - ENSDARP00000065858
NCBI entrez gene - 321602     See in Manteia.
RefSeq - NM_212591
RefSeq Peptide - NP_997756
swissprot - A0A0R4II91
swissprot - Q7SXE8
swissprot - Q7T3L5
ZFIN ID - ZDB-GENE-030131-321
Ensembl - ENSDARG00000044811
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK9ENSGALG00000035576Gallus gallus
 CDK9ENSG00000136807Homo sapiens
 Cdk9ENSMUSG00000009555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk13 / cyclin-dependent kinase 13 / Q14004* / Q69ZA1*ENSDARG0000007679129
cdk12 / cyclin-dependent kinase 12 / Q14AX6* / Q9NYV4*ENSDARG0000006372628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030332 cyclin binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle cardiac muscle cell decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
heart decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism neutrophil decreased amount , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin macrophage decreased amount , abnormal
regenerating fin neutrophil decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell amount , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006816 gtf2f2b / general transcription factor IIF, polypeptide 2b / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / complex
 ENSDARG00000069910 gtf2f2a / general transcription factor IIF, polypeptide 2a / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / complex
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSDARG00000036685 ccnt2a / cyclin T2a / CCNT2* / O60583* / Q7TQK0* / cyclin T2*  / reaction / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / reaction






 

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