ENSG00000136807


Homo sapiens

Features
Gene ID: ENSG00000136807
  
Biological name :CDK9
  
Synonyms : CDK9 / cyclin dependent kinase 9 / P50750
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.11
Gene start: 127785679
Gene end: 127790787
  
Corresponding Affymetrix probe sets: 203198_at (Human Genome U133 Plus 2.0 Array)   228901_at (Human Genome U133 Plus 2.0 Array)   236023_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395872
Ensembl peptide - ENSP00000362361
NCBI entrez gene - 1025     See in Manteia.
OMIM - 603251
RefSeq - XM_017014184
RefSeq - NM_001261
RefSeq Peptide - NP_001252
swissprot - P50750
swissprot - X6RE90
swissprot - A0A024R880
Ensembl - ENSG00000136807
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk9ENSDARG00000044811Danio rerio
 CDK9ENSGALG00000035576Gallus gallus
 Cdk9ENSMUSG00000009555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK13 / Q14004 / cyclin dependent kinase 13ENSG0000006588331
CDK12 / Q9NYV4 / cyclin dependent kinase 12ENSG0000016725831


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006282 regulation of DNA repair IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031056 regulation of histone modification IDA
 biological_processGO:0031297 replication fork processing IDA
 biological_processGO:0033129 positive regulation of histone phosphorylation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:0051147 regulation of muscle cell differentiation IMP
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IBA
 biological_processGO:0071157 negative regulation of cell cycle arrest IDA
 biological_processGO:0071345 cellular response to cytokine stimulus IDA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IMP
 biological_processGO:1903839 positive regulation of mRNA 3"-UTR binding IDA
 biological_processGO:2001168 positive regulation of histone H2B ubiquitination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex TAS
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017069 snRNA binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030332 cyclin binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0097322 7SK snRNA binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / complex / reaction
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction / complex
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction / complex






 

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