ENSG00000204356


Homo sapiens

Features
Gene ID: ENSG00000204356
  
Biological name :NELFE
  
Synonyms : negative elongation factor complex member E / NELFE / P18615
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31952087
Gene end: 31959110
  
Corresponding Affymetrix probe sets: 209219_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364578
Ensembl peptide - ENSP00000388400
Ensembl peptide - ENSP00000486884
Ensembl peptide - ENSP00000420205
Ensembl peptide - ENSP00000419183
Ensembl peptide - ENSP00000414029
Ensembl peptide - ENSP00000409389
Ensembl peptide - ENSP00000397914
Ensembl peptide - ENSP00000394340
Ensembl peptide - ENSP00000364574
NCBI entrez gene - 7936     See in Manteia.
OMIM - 154040
RefSeq - NM_002904
RefSeq - XM_006715205
RefSeq - XM_011514913
RefSeq - XM_017011299
RefSeq Peptide - NP_002895
swissprot - A0A0A0MT02
swissprot - E9PD43
swissprot - P18615
swissprot - A0A0A0MSN9
swissprot - E7EWR7
swissprot - E7ENC7
swissprot - A2ABK4
swissprot - A0A1U9X830
Ensembl - ENSG00000204356
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nelfeENSDARG00000004343Danio rerio
 NelfeENSMUSG00000024369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR033102  Negative elongation factor E
 IPR034637  Negative elongation factor E, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IMP
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0032021 NELF complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction / complex
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction / complex
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / complex / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction / complex
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction / complex
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction






 

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