ENSG00000114503


Homo sapiens

Features
Gene ID: ENSG00000114503
  
Biological name :NCBP2
  
Synonyms : NCBP2 / nuclear cap binding protein subunit 2 / P52298
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q29
Gene start: 196935402
Gene end: 196942597
  
Corresponding Affymetrix probe sets: 201517_at (Human Genome U133 Plus 2.0 Array)   201521_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397619
Ensembl peptide - ENSP00000414122
Ensembl peptide - ENSP00000413518
Ensembl peptide - ENSP00000412785
Ensembl peptide - ENSP00000402549
Ensembl peptide - ENSP00000326806
Ensembl peptide - ENSP00000389315
Ensembl peptide - ENSP00000394105
NCBI entrez gene - 22916     See in Manteia.
OMIM - 605133
RefSeq - XM_011512558
RefSeq - NM_001042540
RefSeq - NM_001308036
RefSeq - NM_007362
RefSeq - XM_011512556
RefSeq - XM_011512557
RefSeq Peptide - NP_001036005
RefSeq Peptide - NP_031388
RefSeq Peptide - NP_001294965
swissprot - F8WE41
swissprot - C9JQX9
swissprot - P52298
swissprot - B3KSB0
swissprot - C9JKF4
Ensembl - ENSG00000114503
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncbp2ENSDARG00000014898Danio rerio
 NCBP2ENSGALG00000006843Gallus gallus
 Ncbp2ENSMUSG00000022774Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A6PVI3 / NCBP2L / nuclear cap binding protein subunit 2 likeENSG0000017093564


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR027157  Nuclear cap-binding protein subunit 2
 IPR034148  NCBP2, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006408 snRNA export from nucleus NAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IDA
 biological_processGO:0008334 histone mRNA metabolic process TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IMP
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045292 mRNA cis splicing, via spliceosome IEA
 biological_processGO:0046833 positive regulation of RNA export from nucleus ISS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051168 nuclear export TAS
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0005846 nuclear cap binding complex IEA
 cellular_componentGO:0034518 RNA cap binding complex IMP
 molecular_functionGO:0000339 RNA cap binding IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017069 snRNA binding IDA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Abortive elongation of HIV-1 transcript in the absence of Tat
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing
Processing of Capped Intron-Containing Pre-mRNA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Signaling by FGFR2 IIIa TM
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction / complex
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction / complex
 ENSG00000101138 CSTF1 / Q05048 / cleavage stimulation factor subunit 1  / reaction / complex
 ENSG00000100227 Q9BY77 / POLDIP3 / DNA polymerase delta interacting protein 3  / complex
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000165819 METTL3 / Q86U44 / methyltransferase like 3  / reaction
 ENSG00000142528 Q8WTR7 / ZNF473 / zinc finger protein 473  / complex / reaction
 ENSG00000164902 PHAX / Q9H814 / phosphorylated adaptor for RNA export  / reaction / complex
 ENSG00000162231 NXF1 / Q9UBU9 / nuclear RNA export factor 1  / reaction
 ENSG00000176102 CSTF3 / Q12996 / cleavage stimulation factor subunit 3  / reaction / complex
 ENSG00000177613 CSTF2T / Q9H0L4 / cleavage stimulation factor subunit 2 tau variant  / reaction / complex
 ENSG00000146457 WTAP / Q15007 / WT1 associated protein  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / complex / reaction
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction
 ENSG00000135486 P09651 / HNRNPA1 / heterogeneous nuclear ribonucleoprotein A1  / complex / reaction
 ENSG00000011304 PTBP1 / P26599 / polypyrimidine tract binding protein 1  / reaction / complex
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / complex / reaction
 ENSG00000070756 P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1  / complex
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction / complex
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / complex / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction / complex
 ENSG00000163950 SLBP / Q14493 / stem-loop binding protein  / complex / reaction
 ENSG00000114867 EIF4G1 / Q04637 / eukaryotic translation initiation factor 4 gamma 1  / complex
 ENSG00000101811 CSTF2 / P33240 / cleavage stimulation factor subunit 2  / reaction / complex
 ENSG00000145388 Q9HCE5 / METTL14 / methyltransferase like 14  / reaction
 ENSG00000087087 SRRT / Q9BXP5 / serrate, RNA effector molecule  / complex / reaction






 

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