ENSG00000165819


Homo sapiens

Features
Gene ID: ENSG00000165819
  
Biological name :METTL3
  
Synonyms : methyltransferase like 3 / METTL3 / Q86U44
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q11.2
Gene start: 21498133
Gene end: 21511375
  
Corresponding Affymetrix probe sets: 209265_s_at (Human Genome U133 Plus 2.0 Array)   213653_at (Human Genome U133 Plus 2.0 Array)   242111_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366766
Ensembl peptide - ENSP00000445523
Ensembl peptide - ENSP00000442407
Ensembl peptide - ENSP00000440598
Ensembl peptide - ENSP00000437692
Ensembl peptide - ENSP00000298717
NCBI entrez gene - 56339     See in Manteia.
OMIM - 612472
RefSeq - NM_019852
RefSeq - XM_006720206
RefSeq - XM_011536968
RefSeq Peptide - NP_062826
swissprot - Q86U44
swissprot - H0YFV6
swissprot - B4DTN4
swissprot - A0A0G2JH39
swissprot - F5H6D8
swissprot - B4E349
Ensembl - ENSG00000165819
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1R777ENSDARG00000012827Danio rerio
 Mettl3ENSMUSG00000022160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007757  MT-A70-like
 IPR025848  mRNA (2-O-methyladenosine-N(6)-)-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IMP
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006382 adenosine to inosine editing ISS
 biological_processGO:0006397 mRNA processing ISS
 biological_processGO:0006402 mRNA catabolic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007623 circadian rhythm ISS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0019827 stem cell population maintenance ISS
 biological_processGO:0021861 forebrain radial glial cell differentiation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031053 primary miRNA processing IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0042063 gliogenesis ISS
 biological_processGO:0045580 regulation of T cell differentiation ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051445 regulation of meiotic cell cycle ISS
 biological_processGO:0061157 mRNA destabilization ISS
 biological_processGO:0080009 mRNA methylation IEA
 biological_processGO:0098508 endothelial to hematopoietic transition ISS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation ISS
 biological_processGO:1903679 positive regulation of cap-independent translational initiation IMP
 biological_processGO:1990744 primary miRNA methylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036396 RNA N6-methyladenosine methyltransferase complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008173 RNA methyltransferase activity IDA
 molecular_functionGO:0016422 mRNA (2"-O-methyladenosine-N6-)-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:1904047 S-adenosyl-L-methionine binding IDA


Pathways (from Reactome)
Pathway description
Processing of Capped Intron-Containing Pre-mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / reaction
 ENSG00000145388 Q9HCE5 / METTL14 / methyltransferase like 14  / complex
 ENSG00000146457 WTAP / Q15007 / WT1 associated protein  / complex
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction






 

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