ENSDARG00000012827


Danio rerio

Features
Gene ID: ENSDARG00000012827
  
Biological name :mettl3
  
Synonyms : F1R777 / methyltransferase like 3 / mettl3
  
Possible biological names infered from orthology : Q86U44
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 21876548
Gene end: 21887104
  
Corresponding Affymetrix probe sets: Dr.1987.1.A1_at (Zebrafish Array)   Dr.1987.2.S1_at (Zebrafish Array)   NM_212780_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022188
NCBI entrez gene - 100004398     See in Manteia.
RefSeq - NM_212780
RefSeq Peptide - NP_997945
swissprot - F1R777
ZFIN ID - ZDB-GENE-030131-9498
Ensembl - ENSDARG00000012827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 METTL3ENSG00000165819Homo sapiens
 Mettl3ENSMUSG00000022160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007757  MT-A70-like
 IPR025848  mRNA (2-O-methyladenosine-N(6)-)-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome ISS
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006382 adenosine to inosine editing ISS
 biological_processGO:0006402 mRNA catabolic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0019827 stem cell population maintenance ISS
 biological_processGO:0021861 forebrain radial glial cell differentiation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031053 primary miRNA processing ISS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034644 cellular response to UV ISS
 biological_processGO:0042063 gliogenesis ISS
 biological_processGO:0042981 regulation of apoptotic process IGI
 biological_processGO:0045580 regulation of T cell differentiation ISS
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0051445 regulation of meiotic cell cycle ISS
 biological_processGO:0061157 mRNA destabilization ISS
 biological_processGO:0080009 mRNA methylation IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 biological_processGO:1903679 positive regulation of cap-independent translational initiation ISS
 biological_processGO:1990744 primary miRNA methylation IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck ISS
 cellular_componentGO:0036396 RNA N6-methyladenosine methyltransferase complex IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008173 RNA methyltransferase activity ISS
 molecular_functionGO:0016422 mRNA (2"-O-methyladenosine-N6-)-methyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:1904047 S-adenosyl-L-methionine binding ISS


Pathways (from Reactome)
Pathway description
Processing of Capped Intron-Containing Pre-mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood estradiol decreased amount , abnormal
blood 11-oxotestosterone decreased amount , abnormal
Show

 ZFA:0000008 brain brain mRNA (2-O-methyladenosine-N6-)-methyltransferase activity decreased occurrence , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000123 liver liver mRNA (2-O-methyladenosine-N6-)-methyltransferase activity decreased occurrence , abnormal
Show

 ZFA:0000135 notochord notochord curved ventral , abnormal
Show

 ZFA:0000242 male organism male organism hypophysis decreased amount , abnormal
Show

 ZFA:0000303 female organism female organism proportionality to male organism , abnormal
female organism decreased female fertility , abnormal
female organism has fewer parts of type oocyte stage V , abnormal
female organism ovulation decreased rate , abnormal
female organism hypophysis decreased amount , abnormal
Show

 ZFA:0000403 ovary ovary decreased size , abnormal
ovary has fewer parts of type ovarian follicle stage IV , abnormal
ovary mRNA (2-O-methyladenosine-N6-)-methyltransferase activity decreased occurrence , abnormal
Show

 ZFA:0000598 testis testis decreased size , abnormal
testis decreased amount , abnormal
testis lacks parts or has fewer parts of type sperm , abnormal
testis has extra parts of type spermatocyte , abnormal
testis has extra parts of type spermatogonium , abnormal
testis mRNA (2-O-methyladenosine-N6-)-methyltransferase activity decreased occurrence , abnormal
Show

 ZFA:0001078 thymus thymus has fewer parts of type T cell , abnormal
thymus lymphocyte decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism amount , ameliorated
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism dead , abnormal
whole organism brood viability , abnormal
whole organism viability , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
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 ZFA:0001264 ovarian follicle stage IV ovarian follicle stage IV increased amount , abnormal
ovarian follicle stage IV decreased amount , abnormal
Show

 ZFA:0001568 oocyte stage IV oocyte stage IV oocyte maturation disrupted , abnormal
oocyte stage IV meiosis II nuclear envelope disassembly disrupted , abnormal
oocyte stage IV meiosis II nuclear envelope disassembly disrupted , ameliorated
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
ventral wall of dorsal aorta lacks parts or has fewer parts of type hematopoietic multipotent progenitor cell , abnormal
Show

 ZFA:0005145 muscle muscle mRNA (2-O-methyladenosine-N6-)-methyltransferase activity decreased occurrence , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042642 wtap / Q7SXL7 / WT1 associated protein / Q9ER69* / Q15007* / Wilms tumour 1-associating protein*  / complex
 ENSDARG00000006816 gtf2f2b / general transcription factor IIF, polypeptide 2b / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / reaction
 ENSDARG00000070278 Q6NZ22 / mettl14 / methyltransferase like 14 / Q9HCE5* / Q3UIK4* / N6-adenosine-methyltransferase non-catalytic subunit *  / complex
 ENSDARG00000014898 ncbp2 / Q8JGR6 / nuclear cap binding protein subunit 2 / Q9CQ49* / NCBP2L* / P52298* / A6PVI3* / nuclear cap binding protein subunit 2 like*  / reaction
 ENSDARG00000069910 gtf2f2a / general transcription factor IIF, polypeptide 2a / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / reaction






 

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