ENSMUSG00000022160


Mus musculus

Features
Gene ID: ENSMUSG00000022160
  
Biological name :Mettl3
  
Synonyms : methyltransferase like 3 / Mettl3
  
Possible biological names infered from orthology : Q86U44
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 52294841
Gene end: 52305128
  
Corresponding Affymetrix probe sets: 10419691 (MoGene1.0st)   1423099_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134732
Ensembl peptide - ENSMUSP00000134577
Ensembl peptide - ENSMUSP00000134578
Ensembl peptide - ENSMUSP00000022767
Ensembl peptide - ENSMUSP00000133506
Ensembl peptide - ENSMUSP00000133573
Ensembl peptide - ENSMUSP00000133759
Ensembl peptide - ENSMUSP00000133864
Ensembl peptide - ENSMUSP00000133999
Ensembl peptide - ENSMUSP00000134018
NCBI entrez gene - 56335     See in Manteia.
MGI - MGI:1927165
RefSeq - XM_017316096
RefSeq - NM_019721
RefSeq - XM_006519311
RefSeq Peptide - NP_062695
swissprot - G3UYB5
swissprot - G3UZP2
swissprot - G3UZP3
swissprot - G5E922
swissprot - G3UX68
swissprot - A0A0R4J041
swissprot - G3UXN3
swissprot - G3UY98
swissprot - G3UXX7
Ensembl - ENSMUSG00000022160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1R777ENSDARG00000012827Danio rerio
 METTL3ENSG00000165819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007757  MT-A70-like
 IPR025848  mRNA (2-O-methyladenosine-N(6)-)-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031053 primary miRNA processing IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0080009 mRNA methylation IEA
 biological_processGO:1903679 positive regulation of cap-independent translational initiation IEA
 biological_processGO:1990744 primary miRNA methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036396 RNA N6-methyladenosine methyltransferase complex IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0008173 RNA methyltransferase activity IEA
 molecular_functionGO:0016422 mRNA (2"-O-methyladenosine-N6-)-methyltransferase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:1904047 S-adenosyl-L-methionine binding IEA


Pathways (from Reactome)
Pathway description
Processing of Capped Intron-Containing Pre-mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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