ENSG00000145388


Homo sapiens

Features
Gene ID: ENSG00000145388
  
Biological name :METTL14
  
Synonyms : methyltransferase like 14 / METTL14 / Q9HCE5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q26
Gene start: 118685368
Gene end: 118715433
  
Corresponding Affymetrix probe sets: 227601_at (Human Genome U133 Plus 2.0 Array)   235552_at (Human Genome U133 Plus 2.0 Array)   236060_at (Human Genome U133 Plus 2.0 Array)   241689_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373474
Ensembl peptide - ENSP00000486933
Ensembl peptide - ENSP00000486381
Ensembl peptide - ENSP00000425460
Ensembl peptide - ENSP00000424111
NCBI entrez gene - 57721     See in Manteia.
OMIM - 616504
RefSeq - XM_011532162
RefSeq - NM_020961
RefSeq - XM_005263166
RefSeq Peptide - NP_066012
swissprot - D6RBL4
swissprot - D6RD73
swissprot - Q9HCE5
swissprot - A0A0D9SFW0
swissprot - A0A0D9SF88
Ensembl - ENSG00000145388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NZ22ENSDARG00000070278Danio rerio
 Q5ZK35ENSGALG00000012000Gallus gallus
 Q3UIK4ENSMUSG00000028114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007757  MT-A70-like
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IMP
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006402 mRNA catabolic process IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0021861 forebrain radial glial cell differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042063 gliogenesis IEA
 biological_processGO:0061157 mRNA destabilization IEA
 biological_processGO:0080009 mRNA methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0036396 RNA N6-methyladenosine methyltransferase complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016422 mRNA (2"-O-methyladenosine-N6-)-methyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Processing of Capped Intron-Containing Pre-mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165819 METTL3 / Q86U44 / methyltransferase like 3  / complex
 ENSG00000146457 WTAP / Q15007 / WT1 associated protein  / complex
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction






 

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