ENSG00000011304


Homo sapiens

Features
Gene ID: ENSG00000011304
  
Biological name :PTBP1
  
Synonyms : P26599 / polypyrimidine tract binding protein 1 / PTBP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 797075
Gene end: 812327
  
Corresponding Affymetrix probe sets: 202189_x_at (Human Genome U133 Plus 2.0 Array)   211270_x_at (Human Genome U133 Plus 2.0 Array)   211271_x_at (Human Genome U133 Plus 2.0 Array)   212015_x_at (Human Genome U133 Plus 2.0 Array)   212016_s_at (Human Genome U133 Plus 2.0 Array)   216306_x_at (Human Genome U133 Plus 2.0 Array)   226491_x_at (Human Genome U133 Plus 2.0 Array)   231158_x_at (Human Genome U133 Plus 2.0 Array)   236819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465825
Ensembl peptide - ENSP00000489604
Ensembl peptide - ENSP00000486218
Ensembl peptide - ENSP00000478974
Ensembl peptide - ENSP00000478414
Ensembl peptide - ENSP00000478097
Ensembl peptide - ENSP00000468565
Ensembl peptide - ENSP00000466250
Ensembl peptide - ENSP00000014112
Ensembl peptide - ENSP00000342332
Ensembl peptide - ENSP00000349428
Ensembl peptide - ENSP00000408096
Ensembl peptide - ENSP00000465451
Ensembl peptide - ENSP00000465652
NCBI entrez gene - 5725     See in Manteia.
OMIM - 600693
RefSeq - NM_031990
RefSeq - NM_031991
RefSeq - NM_002819
RefSeq - XM_005259597
RefSeq - XM_005259598
RefSeq Peptide - NP_002810
RefSeq Peptide - NP_114367
RefSeq Peptide - NP_114368
swissprot - A6NLN1
swissprot - K7ES59
swissprot - P26599
swissprot - K7ELW5
swissprot - A0A0U1RRM4
swissprot - A0A0D9SF20
swissprot - A0A087WUW5
swissprot - A0A087WU68
swissprot - A0A087WTS6
swissprot - K7EK45
swissprot - K7EKJ7
swissprot - K7EKX4
Ensembl - ENSG00000011304
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptbp1aENSDARG00000019362Danio rerio
 ptbp1bENSDARG00000031907Danio rerio
 PTBP1ENSGALG00000001962Gallus gallus
 Ptbp1ENSMUSG00000006498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTBP3 / O95758 / polypyrimidine tract binding protein 3ENSG0000011931476
PTBP2 / Q9UKA9 / polypyrimidine tract binding protein 2ENSG0000011756972
HNRNPL / P14866 / heterogeneous nuclear ribonucleoprotein LENSG0000010482427
Q8WVV9 / HNRNPLL / heterogeneous nuclear ribonucleoprotein L likeENSG0000014388925
AC008982.1ENSG0000026808310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR006536  HnRNP-L/PTB
 IPR034798  Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2
 IPR035000  PTBP1, RNA recognition motif 1
 IPR035001  PTBP1, RNA recognition motif 3
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0033119 negative regulation of RNA splicing IDA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 biological_processGO:0051148 negative regulation of muscle cell differentiation IDA
 biological_processGO:0075522 IRES-dependent viral translational initiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008187 poly-pyrimidine tract binding TAS
 molecular_functionGO:0036002 pre-mRNA binding IDA


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction / complex
 ENSG00000135486 P09651 / HNRNPA1 / heterogeneous nuclear ribonucleoprotein A1  / complex / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction / complex
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction / complex






 

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