ENSMUSG00000022774


Mus musculus

Features
Gene ID: ENSMUSG00000022774
  
Biological name :Ncbp2
  
Synonyms : Ncbp2 / Nuclear cap-binding protein subunit 2 / Q9CQ49
  
Possible biological names infered from orthology : P52298
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B2
Gene start: 31948513
Gene end: 31961781
  
Corresponding Affymetrix probe sets: 10434998 (MoGene1.0st)   1423045_at (Mouse Genome 430 2.0 Array)   1423046_s_at (Mouse Genome 430 2.0 Array)   1450847_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110832
Ensembl peptide - ENSMUSP00000023460
NCBI entrez gene - 68092     See in Manteia.
MGI - MGI:1915342
RefSeq - NM_026554
RefSeq Peptide - NP_080830
swissprot - D3Z3D2
swissprot - Q9CQ49
Ensembl - ENSMUSG00000022774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncbp2ENSDARG00000014898Danio rerio
 NCBP2ENSGALG00000006843Gallus gallus
 NCBP2ENSG00000114503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR027157  Nuclear cap-binding protein subunit 2
 IPR034148  NCBP2, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006408 snRNA export from nucleus ISS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IEA
 biological_processGO:0008380 RNA splicing ISS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031442 positive regulation of mRNA 3"-end processing IEA
 biological_processGO:0045292 mRNA cis splicing, via spliceosome ISO
 biological_processGO:0046833 positive regulation of RNA export from nucleus ISS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0005846 nuclear cap binding complex IBA
 cellular_componentGO:0034518 RNA cap binding complex IEA
 molecular_functionGO:0000339 RNA cap binding IBA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0017069 snRNA binding ISS


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of Mature mRNA derived from an Intron-Containing Transcript
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing
Processing of Capped Intron-Containing Pre-mRNA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003435 Supt5 / O55201 / Transcription elongation factor SPT5 / O00267* / SUPT5H* / SPT5 homolog, DSIF elongation factor subunit*  / complex / reaction
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / reaction / complex
 ENSMUSG00000060475 Wtap / Q9ER69 / Wilms tumour 1-associating protein / Q15007* / WT1 associated protein*  / reaction
 ENSMUSG00000008301 Phax / Q9JJT9 / phosphorylated adaptor for RNA export / Q9H814*  / complex / reaction
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000031256 Cstf2 / Q8BIQ5 / Cleavage stimulation factor subunit 2 / P33240*  / complex / reaction
 ENSMUSG00000027176 Cstf3 / Q99LI7 / Cleavage stimulation factor subunit 3 / Q12996*  / complex / reaction
 ENSMUSG00000027498 Cstf1 / Q99LC2 / Cleavage stimulation factor subunit 1 / Q05048*  / complex / reaction
 ENSMUSG00000053536 Cstf2t / Q8C7E9 / Cleavage stimulation factor subunit 2 tau variant / Q9H0L4*  / complex / reaction
 ENSMUSG00000046434 P49312 / Hnrnpa1 / Heteroous nuclear ribonucleoprotein A1 Heteroous nuclear ribonucleoprotein A1, N-terminally processed / P09651* / heterogeneous nuclear ribonucleoprotein A1*  / complex / reaction
 ENSMUSG00000033323 Ctdp1 / Q7TSG2 / RNA polymerase II subunit A C-terminal domain phosphatase / Q9Y5B0* / CTD phosphatase subunit 1*  / complex / reaction
 ENSMUSG00000029111 Nelfa / Q8BG30 / Negative elongation factor A / Q9H3P2* / negative elongation factor complex member A*  / complex / reaction
 ENSMUSG00000037364 Srrt / Q99MR6 / Serrate RNA effector molecule homolog / Q9BXP5* / serrate, RNA effector molecule*  / complex / reaction
 ENSMUSG00000028114 Q3UIK4 / Mettl14 / N6-adenosine-methyltransferase non-catalytic subunit / Q9HCE5* / methyltransferase like 14*  / reaction
 ENSMUSG00000004642 Slbp / P97440 / stem-loop binding protein / Q14493*  / complex / reaction
 ENSMUSG00000041815 Q8BG81 / Poldip3 / Mus musculus polymerase (DNA-directed), delta interacting protein 3 (Poldip3), transcript variant 2, mRNA. / Q9BY77* / DNA polymerase delta interacting protein 3*  / complex
 ENSMUSG00000048012 Q8BI67 / Zfp473 / zinc finger protein 473 / Q8WTR7* / ZNF473*  / reaction / complex
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / complex
 ENSMUSG00000051732 Pabpc2 / P11940* / PABPC1* / poly(A) binding protein cytoplasmic 1*  / complex
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / complex / reaction
 ENSMUSG00000020485 P63271 / Supt4a / suppressor of Ty 4A / P63272* / SUPT4H1* / SPT4 homolog, DSIF elongation factor subunit*  / reaction / complex
 ENSMUSG00000024369 Nelfe / P19426 / negative elongation factor complex member E, Rdbp / P18615* / negative elongation factor complex member E*  / complex / reaction






 

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