ENSMUSG00000053536


Mus musculus

Features
Gene ID: ENSMUSG00000053536
  
Biological name :Cstf2t
  
Synonyms : Cleavage stimulation factor subunit 2 tau variant / Cstf2t / Q8C7E9
  
Possible biological names infered from orthology : Q9H0L4
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 31082841
Gene end: 31086590
  
Corresponding Affymetrix probe sets: 10462480 (MoGene1.0st)   1415920_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093831
NCBI entrez gene - 83410     See in Manteia.
MGI - MGI:1932622
RefSeq - NM_031249
RefSeq Peptide - NP_112539
swissprot - Q8C7E9
Ensembl - ENSMUSG00000053536
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cstf2ENSDARG00000090788Danio rerio
 CSTF2ENSGALG00000006760Gallus gallus
 CSTF2TENSG00000177613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cstf2 / Q8BIQ5 / Cleavage stimulation factor subunit 2 / P33240*ENSMUSG0000003125666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR025742  Cleavage stimulation factor subunit 2, hinge domain
 IPR026896  Transcription termination and cleavage factor, C-terminal domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006378 mRNA polyadenylation TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0031124 mRNA 3"-end processing IEA
 biological_processGO:0098789 pre-mRNA cleavage required for polyadenylation IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003729 mRNA binding IBA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Hes1tm1Kag/Hes1tm1Kag,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022774 Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*  / complex / reaction
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000027176 Cstf3 / Q99LI7 / Cleavage stimulation factor subunit 3 / Q12996*  / complex
 ENSMUSG00000027498 Cstf1 / Q99LC2 / Cleavage stimulation factor subunit 1 / Q05048*  / complex






 

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