Manteia

ENSMUSG00000031256

Mus musculus

Features

Gene ID:	ENSMUSG00000031256

Biological name :	Cstf2

Synonyms :	Cleavage stimulation factor subunit 2 / Cstf2 / Q8BIQ5

Possible biological names infered from orthology :	P33240

Species:	Mus musculus

Chr. number:	X
Strand:	1
Band:	E3
Gene start:	134059187
Gene end:	134086819

Corresponding Affymetrix probe sets:	10601673 (MoGene1.0st) 1419644_at (Mouse Genome 430 2.0 Array) 1419645_at (Mouse Genome 430 2.0 Array) 1455523_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000117592 Ensembl peptide - ENSMUSP00000108912 Ensembl peptide - ENSMUSP00000117806 Ensembl peptide - ENSMUSP00000114837 Ensembl peptide - ENSMUSP00000033609 Ensembl peptide - ENSMUSP00000108911 NCBI entrez gene - 108062 See in Manteia. MGI - MGI:1343054 RefSeq - XM_006528478 RefSeq - XM_006528481 RefSeq - XM_006528480 RefSeq - XM_006528479 RefSeq - NM_001290398 RefSeq - NM_001290399 RefSeq - NM_133196 RefSeq Peptide - NP_001277327 RefSeq Peptide - NP_001277328 RefSeq Peptide - NP_573459 swissprot - Q8BIQ5 swissprot - A2AEK3 swissprot - A2AEJ8 swissprot - F6ZKC7 swissprot - A2AEK1 Ensembl - ENSMUSG00000031256

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cstf2t / Q8C7E9 / Cleavage stimulation factor subunit 2 tau variant / Q9H0L4*	ENSMUSG00000053536	72

Protein motifs (from Interpro)

Interpro ID	Name
IPR000504	RNA recognition motif domain
IPR025742	Cleavage stimulation factor subunit 2, hinge domain
IPR026896	Transcription termination and cleavage factor, C-terminal domain
IPR033105	Cleavage stimulation factor subunit 2
IPR035979	RNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006378	mRNA polyadenylation	IEA
biological_process	GO:0006397	mRNA processing	IEA
biological_process	GO:0031124	mRNA 3"-end processing	IEA
biological_process	GO:0098789	pre-mRNA cleavage required for polyadenylation	IBA
biological_process	GO:1990090	cellular response to nerve growth factor stimulus	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	ISO
cellular_component	GO:0016604	nuclear body	ISO
cellular_component	GO:0071920	cleavage body	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003723	RNA binding	ISO
molecular_function	GO:0003729	mRNA binding	IBA

Pathways (from Reactome)

Pathway description

Cleavage of Growing Transcript in the Termination Region

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: G0s2^tm1Jgte/G0s2^tm1Jgte Genetic Background: involves: 129S7/SvEvBrd
MP:0001685	abnormal endoderm development	"failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: G0s2^tm1Jgte/G0s2^tm1Jgte Genetic Background: involves: 129S7/SvEvBrd
MP:0002399	abnormal pluripotent precursor cell morphology/development	"anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: G0s2^tm1Jgte/G0s2^tm1Jgte Genetic Background: involves: 129S7/SvEvBrd
MP:0002663	failure to form blastocele	"developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]	Show Allelic Composition: G0s2^tm1Jgte/G0s2^tm1Jgte Genetic Background: involves: 129S7/SvEvBrd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022774	Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*	/ complex / reaction
ENSMUSG00000027498	Cstf1 / Q99LC2 / Cleavage stimulation factor subunit 1 / Q05048*	/ complex
ENSMUSG00000028330	Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*	/ reaction / complex
ENSMUSG00000027176	Cstf3 / Q99LI7 / Cleavage stimulation factor subunit 3 / Q12996*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr