ENSMUSG00000046434


Mus musculus

Features
Gene ID: ENSMUSG00000046434
  
Biological name :Hnrnpa1
  
Synonyms : Heteroous nuclear ribonucleoprotein A1 Heteroous nuclear ribonucleoprotein A1, N-terminally processed / Hnrnpa1 / P49312
  
Possible biological names infered from orthology : heterogeneous nuclear ribonucleoprotein A1 / P09651
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 103240432
Gene end: 103246692
  
Corresponding Affymetrix probe sets: 10427310 (MoGene1.0st)   10427885 (MoGene1.0st)   10454411 (MoGene1.0st)   10597969 (MoGene1.0st)   10602173 (MoGene1.0st)   1423531_a_at (Mouse Genome 430 2.0 Array)   1430019_a_at (Mouse Genome 430 2.0 Array)   1430020_x_at (Mouse Genome 430 2.0 Array)   1436549_a_at (Mouse Genome 430 2.0 Array)   1455305_x_at (Mouse Genome 430 2.0 Array)   1455740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042658
Ensembl peptide - ENSMUSP00000084609
Ensembl peptide - ENSMUSP00000154865
Ensembl peptide - ENSMUSP00000155311
Ensembl peptide - ENSMUSP00000155833
NCBI entrez gene - 15382     See in Manteia.
MGI - MGI:104820
RefSeq - NM_001039129
RefSeq - NM_010447
RefSeq Peptide - NP_001034218
RefSeq Peptide - NP_034577
swissprot - P49312
swissprot - Q5EBP8
Ensembl - ENSMUSG00000046434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnrnpa1aENSDARG00000011020Danio rerio
 hnrnpa1bENSDARG00000036675Danio rerio
 HNRNPA1ENSGALG00000042011Gallus gallus
 P09651ENSG00000135486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BG05 / Hnrnpa3 / Heteroous nuclear ribonucleoprotein A3 / P51991* / heterogeneous nuclear ribonucleoprotein A3*ENSMUSG0000005900570
Gm9242ENSMUSG0000009615670
Gm6793ENSMUSG0000009208668
O88569 / Hnrnpa2b1 / Heteroous nuclear ribonucleoproteins A2/B1 / P22626* / heterogeneous nuclear ribonucleoprotein A2/B1*ENSMUSG0000000498059
Gm17190ENSMUSG0000009911547
Q9CX86 / Hnrnpa0 / Heteroous nuclear ribonucleoprotein A0 / Q13151* / heterogeneous nuclear ribonucleoprotein A0*ENSMUSG0000000783643


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR021662  Nuclear factor hnRNPA1
 IPR034803  hnRNP A1, RNA recognition motif 2
 IPR034845  hnRNP A1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IDA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IDA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051168 nuclear export ISS
 biological_processGO:0051170 import into nucleus ISS
 biological_processGO:1903936 cellular response to sodium arsenite ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005681 spliceosomal complex ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035198 miRNA binding ISS
 molecular_functionGO:0036002 pre-mRNA binding IEA
 molecular_functionGO:0061752 telomeric repeat-containing RNA binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0004070 abnormal P wave "any anomaly in the P wave which is normally caused by atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

 MP:0030421 tongue muscle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the muscular portion of the tongue" [MGI:anna]
Show

Allelic Composition: Gria4spkw1/Gria4spkw1,Pcnx2em5Frk/Pcnx2em5Frk
Genetic Background: C3Fe.C3-Pcnx2em5Frk Gria4spkw1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / complex / reaction
 ENSMUSG00000022774 Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*  / complex / reaction
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / complex / reaction






 

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