Manteia

ENSMUSG00000003435

Mus musculus

Features

Gene ID:	ENSMUSG00000003435

Biological name :	Supt5

Synonyms :	O55201 / Supt5 / Transcription elongation factor SPT5

Possible biological names infered from orthology :	O00267 / SPT5 homolog, DSIF elongation factor subunit / SUPT5H

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	A3
Gene start:	28314891
Gene end:	28338746

Corresponding Affymetrix probe sets:	10561401 (MoGene1.0st) 1424255_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146961 Ensembl peptide - ENSMUSP00000147164 Ensembl peptide - ENSMUSP00000147059 Ensembl peptide - ENSMUSP00000003527 NCBI entrez gene - 20924 See in Manteia. MGI - MGI:1202400 RefSeq - XM_006539702 RefSeq - XM_006539703 RefSeq - NM_013676 RefSeq Peptide - NP_038704 swissprot - O55201 swissprot - A0A140LJ34 swissprot - A0A140LIU5 Ensembl - ENSMUSG00000003435

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR005100	Transcription elongation factor Spt5, NGN domain
IPR005824	KOW
IPR006645	NusG, N-terminal
IPR008991	Translation protein SH3-like domain superfamily
IPR014722	Ribosomal protein L2, domain 2
IPR017071	Transcription elongation factor Spt5
IPR022581	Spt5 transcription elongation factor, N-terminal
IPR024945	Spt5 C-terminal domain
IPR036735	NusG, N-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006354	DNA-templated transcription, elongation	ISO
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0006368	transcription elongation from RNA polymerase II promoter	IEA
biological_process	GO:0006397	mRNA processing	IBA
biological_process	GO:0016239	positive regulation of macroautophagy	IEA
biological_process	GO:0032784	regulation of DNA-templated transcription, elongation	IEA
biological_process	GO:0032785	negative regulation of DNA-templated transcription, elongation	IEA
biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:1900364	negative regulation of mRNA polyadenylation	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0032044	DSIF complex	IEA
molecular_function	GO:0003677	DNA binding	IBA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003729	mRNA binding	IBA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA

Pathways (from Reactome)

Pathway description

Formation of RNA Pol II elongation complex

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003036	vertebral transformation	"homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020485	P63271 / Supt4a / suppressor of Ty 4A / P63272* / SUPT4H1* / SPT4 homolog, DSIF elongation factor subunit*	/ complex / reaction
ENSMUSG00000022774	Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*	/ complex / reaction
ENSMUSG00000028330	Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*	/ complex / reaction
ENSMUSG00000033323	Ctdp1 / Q7TSG2 / RNA polymerase II subunit A C-terminal domain phosphatase / Q9Y5B0* / CTD phosphatase subunit 1*	/ reaction / complex
ENSMUSG00000002658	Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*	/ reaction
ENSMUSG00000009535	Rnmt / Q9D0L8 / RNA (guanine-7-) methyltransferase / O43148*	/ reaction
ENSMUSG00000028274	Rngtt / O55236 / RNA guanylyltransferase and 5-phosphatase / O60942*	/ reaction
ENSMUSG00000029111	Nelfa / Q8BG30 / Negative elongation factor A / Q9H3P2* / negative elongation factor complex member A*	/ complex / reaction
ENSMUSG00000067995	Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*	/ reaction
ENSMUSG00000024369	Nelfe / P19426 / negative elongation factor complex member E, Rdbp / P18615* / negative elongation factor complex member E*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr