ENSDARG00000042724


Danio rerio

Features
Gene ID: ENSDARG00000042724
  
Biological name :supt5h
  
Synonyms : SPT5 homolog, DSIF elongation factor subunit / supt5h
  
Possible biological names infered from orthology : O00267 / O55201 / Supt5 / Transcription elongation factor SPT5
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 20363859
Gene end: 20395249
  
Corresponding Affymetrix probe sets: Dr.20907.1.S1_at (Zebrafish Array)   NM_131673_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132237
Ensembl peptide - ENSDARP00000062675
NCBI entrez gene - 64275     See in Manteia.
RefSeq - NM_131673
RefSeq - XM_005157529
RefSeq - XM_021481462
RefSeq - XM_021481463
RefSeq Peptide - NP_571748
swissprot - F1QD27
swissprot - A0A0R4IBG8
ZFIN ID - ZDB-GENE-001207-1
Ensembl - ENSDARG00000042724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZI08ENSGALG00000039160Gallus gallus
 O00267ENSG00000196235Homo sapiens
 Supt5ENSMUSG00000003435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005100  Transcription elongation factor Spt5, NGN domain
 IPR005824  KOW
 IPR006645  NusG, N-terminal
 IPR008991  Translation protein SH3-like domain superfamily
 IPR014722  Ribosomal protein L2, domain 2
 IPR017071  Transcription elongation factor Spt5
 IPR022581  Spt5 transcription elongation factor, N-terminal
 IPR024945  Spt5 C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 cellular_componentGO:0005634 nucleus IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
RNA Polymerase II Transcription Elongation
RNA Pol II CTD phosphorylation and interaction with CE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm thrombocyte decreased amount , abnormal
intermediate cell mass of mesoderm hematopoietic multipotent progenitor cell amount , ameliorated
intermediate cell mass of mesoderm hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart edematous , abnormal
Show

 ZFA:0000152 retina retina lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000155 somite somite degenerate , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000360 heart tube heart tube poorly differentiated , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001078 thymus thymus T cell absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism dead , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region quality , abnormal
post-vent region morphology , abnormal
post-vent region decreased length , abnormal
Show

 ZFA:0001202 optic cup optic cup morphology , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic stem cell amount , ameliorated
ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009052 motor neuron motor neuron quality , abnormal
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 ZFA:0009065 endothelial cell endothelial cell increased amount , abnormal
endothelial cell decreased amount , abnormal
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 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009091 melanocyte melanocyte absent , abnormal
melanocyte decreased amount , abnormal
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 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
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 ZFA:0009248 neuron neuron apoptotic , abnormal
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 ZFA:0009301 dopaminergic neuron dopaminergic neuron neuron development disrupted , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell amount , ameliorated
hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell cell proliferation occurrence , ameliorated
hematopoietic multipotent progenitor cell cell proliferation decreased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006816 gtf2f2b / general transcription factor IIF, polypeptide 2b / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / reaction
 ENSDARG00000014898 ncbp2 / Q8JGR6 / nuclear cap binding protein subunit 2 / Q9CQ49* / NCBP2L* / P52298* / A6PVI3* / nuclear cap binding protein subunit 2 like*  / reaction / complex
 ENSDARG00000032261 rngtt / Q6NY98 / RNA guanylyltransferase and 5-phosphatase / O55236* / O60942*  / reaction
 ENSDARG00000070553 rnmt / Q1MTD3 / RNA (guanine-7-) methyltransferase / O43148* / Q9D0L8*  / reaction
 ENSDARG00000069910 gtf2f2a / general transcription factor IIF, polypeptide 2a / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / reaction
 ENSDARG00000061411 nelfa / negative elongation factor complex member A / Q8BG30* / Q9H3P2* / Negative elongation factor A *  / reaction / complex
 ENSDARG00000004343 nelfe / negative elongation factor complex member E / P18615* / P19426* / negative elongation factor complex member E, Rdbp*  / reaction / complex
 ENSDARG00000113969 Q6DGQ0 / supt4h1 / SPT4 homolog, DSIF elongation factor subunit / P63272*  / reaction / complex






 

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