ENSG00000196235


Homo sapiens

Features
Gene ID: ENSG00000196235
  
Biological name :SUPT5H
  
Synonyms : O00267 / SPT5 homolog, DSIF elongation factor subunit / SUPT5H
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 39436156
Gene end: 39476670
  
Corresponding Affymetrix probe sets: 201480_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472675
Ensembl peptide - ENSP00000470595
Ensembl peptide - ENSP00000471561
Ensembl peptide - ENSP00000352117
Ensembl peptide - ENSP00000384505
Ensembl peptide - ENSP00000404029
Ensembl peptide - ENSP00000469090
Ensembl peptide - ENSP00000469915
Ensembl peptide - ENSP00000470252
NCBI entrez gene - 6829     See in Manteia.
OMIM - 602102
RefSeq - XM_017027174
RefSeq - NM_001111020
RefSeq - NM_001130824
RefSeq - NM_001130825
RefSeq - NM_001319990
RefSeq - NM_001319991
RefSeq - NM_003169
RefSeq Peptide - NP_001124297
RefSeq Peptide - NP_001306919
RefSeq Peptide - NP_001306920
RefSeq Peptide - NP_003160
RefSeq Peptide - NP_001104490
RefSeq Peptide - NP_001124296
swissprot - M0R2M5
swissprot - M0QYL9
swissprot - M0R105
swissprot - O00267
Ensembl - ENSG00000196235
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 supt5hENSDARG00000042724Danio rerio
 Q5ZI08ENSGALG00000039160Gallus gallus
 Supt5ENSMUSG00000003435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005100  Transcription elongation factor Spt5, NGN domain
 IPR005824  KOW
 IPR006645  NusG, N-terminal
 IPR008991  Translation protein SH3-like domain superfamily
 IPR014722  Ribosomal protein L2, domain 2
 IPR017071  Transcription elongation factor Spt5
 IPR022581  Spt5 transcription elongation factor, N-terminal
 IPR024945  Spt5 C-terminal domain
 IPR036735  NusG, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032785 negative regulation of DNA-templated transcription, elongation IMP
 biological_processGO:0032786 positive regulation of DNA-templated transcription, elongation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032044 DSIF complex IDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
RNA Polymerase II Transcription Elongation
RNA Pol II CTD phosphorylation and interaction with CE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction / complex
 ENSG00000129315 CCNT1 / O60563 / cyclin T1  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / complex / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction / complex
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / complex / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction / complex
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction / complex
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction / complex
 ENSG00000101654 RNMT / O43148 / RNA guanine-7 methyltransferase  / reaction
 ENSG00000082258 CCNT2 / O60583 / cyclin T2  / reaction
 ENSG00000111880 RNGTT / O60942 / RNA guanylyltransferase and 5-phosphatase  / reaction
 ENSG00000090061 CCNK / O75909 / cyclin K  / reaction






 

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