ENSG00000129315


Homo sapiens

Features
Gene ID: ENSG00000129315
  
Biological name :CCNT1
  
Synonyms : CCNT1 / cyclin T1 / O60563
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 48688458
Gene end: 48716998
  
Corresponding Affymetrix probe sets: 206967_at (Human Genome U133 Plus 2.0 Array)   225493_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481035
Ensembl peptide - ENSP00000491861
Ensembl peptide - ENSP00000261900
Ensembl peptide - ENSP00000399845
NCBI entrez gene - 904     See in Manteia.
OMIM - 143055
RefSeq - XM_017020197
RefSeq - NM_001240
RefSeq - NM_001277842
RefSeq Peptide - NP_001231
RefSeq Peptide - NP_001264771
swissprot - O60563
swissprot - A0A1W2PQ16
Ensembl - ENSG00000129315
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnt1ENSDARG00000017525Danio rerio
 Ccnt1ENSMUSG00000011960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNT2 / O60583 / cyclin T2ENSG0000008225849
CCNK / O75909 / cyclin KENSG0000009006119
CCNL2 / Q96S94 / cyclin L2ENSG0000022197816
CCNL1 / Q9UK58 / cyclin L1ENSG0000016366015
CCNC / P24863 / cyclin CENSG000001122379
CCNQ / Q8N1B3 / cyclin QENSG000002629196


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028863  Cyclin-T1
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IPI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0043923 positive regulation by host of viral transcription NAS
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IMP
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA
 molecular_functionGO:0017069 snRNA binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IPI
 molecular_functionGO:0097322 7SK snRNA binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060069 CTDP1 / Q9Y5B0 / CTD phosphatase subunit 1  / reaction
 ENSG00000213246 P63272 / SUPT4H1 / SPT4 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000204356 NELFE / P18615 / negative elongation factor complex member E  / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction
 ENSG00000136807 CDK9 / P50750 / cyclin dependent kinase 9  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction
 ENSG00000185049 NELFA / Q9H3P2 / negative elongation factor complex member A  / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / reaction
 ENSG00000114503 NCBP2 / P52298 / nuclear cap binding protein subunit 2  / reaction
 ENSG00000136937 NCBP1 / Q09161 / nuclear cap binding protein subunit 1  / reaction
 ENSG00000196235 O00267 / SUPT5H / SPT5 homolog, DSIF elongation factor subunit  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex






 

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