ENSMUSG00000029111


Mus musculus

Features
Gene ID: ENSMUSG00000029111
  
Biological name :Nelfa
  
Synonyms : Negative elongation factor A / Nelfa / Q8BG30
  
Possible biological names infered from orthology : negative elongation factor complex member A / Q9H3P2
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 33897916
Gene end: 33936413
  
Corresponding Affymetrix probe sets: 10529330 (MoGene1.0st)   1427248_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030993
NCBI entrez gene - 24116     See in Manteia.
MGI - MGI:1346098
RefSeq - NM_011914
RefSeq Peptide - NP_036044
swissprot - Q8BG30
Ensembl - ENSMUSG00000029111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nelfaENSDARG00000061411Danio rerio
 NELFAENSGALG00000015699Gallus gallus
 NELFAENSG00000185049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR037517  Hepatitis delta antigen (HDAg) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032021 NELF complex ISO
 molecular_functionGO:0003682 chromatin binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022774 Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*  / reaction / complex
 ENSMUSG00000003435 Supt5 / O55201 / Transcription elongation factor SPT5 / O00267* / SUPT5H* / SPT5 homolog, DSIF elongation factor subunit*  / reaction / complex
 ENSMUSG00000020485 P63271 / Supt4a / suppressor of Ty 4A / P63272* / SUPT4H1* / SPT4 homolog, DSIF elongation factor subunit*  / reaction / complex
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000033323 Ctdp1 / Q7TSG2 / RNA polymerase II subunit A C-terminal domain phosphatase / Q9Y5B0* / CTD phosphatase subunit 1*  / reaction / complex
 ENSMUSG00000024369 Nelfe / P19426 / negative elongation factor complex member E, Rdbp / P18615* / negative elongation factor complex member E*  / complex






 

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