ENSMUSG00000020485


Mus musculus

Features
Gene ID: ENSMUSG00000020485
  
Biological name :Supt4a
  
Synonyms : P63271 / suppressor of Ty 4A / Supt4a
  
Possible biological names infered from orthology : P63272 / SPT4 homolog, DSIF elongation factor subunit / SUPT4H1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87737552
Gene end: 87743623
  
Corresponding Affymetrix probe sets: 10368575 (MoGene1.0st)   10380129 (MoGene1.0st)   1422418_s_at (Mouse Genome 430 2.0 Array)   1456353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118619
Ensembl peptide - ENSMUSP00000091487
Ensembl peptide - ENSMUSP00000117762
NCBI entrez gene - 20922     See in Manteia.
MGI - MGI:107416
RefSeq - XM_006532741
RefSeq - XM_006532742
RefSeq - NM_009296
RefSeq Peptide - NP_033322
swissprot - P63271
swissprot - G3UVU8
swissprot - D6RHM5
Ensembl - ENSMUSG00000020485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DGQ0ENSDARG00000113969Danio rerio
 SUPT4H1ENSGALG00000000944Gallus gallus
 P63272ENSG00000213246Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009287  Transcription initiation Spt4
 IPR022800  Spt4/RpoE2 zinc finger
 IPR029040  RNA polymerase subunit RPABC4/transcription elongation factor Spt4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0006397 mRNA processing IBA
 biological_processGO:0032785 negative regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032786 positive regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032044 DSIF complex IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0003727 single-stranded RNA binding IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003435 Supt5 / O55201 / Transcription elongation factor SPT5 / O00267* / SUPT5H* / SPT5 homolog, DSIF elongation factor subunit*  / complex / reaction
 ENSMUSG00000029111 Nelfa / Q8BG30 / Negative elongation factor A / Q9H3P2* / negative elongation factor complex member A*  / complex / reaction
 ENSMUSG00000022774 Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*  / complex / reaction
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000033323 Ctdp1 / Q7TSG2 / RNA polymerase II subunit A C-terminal domain phosphatase / Q9Y5B0* / CTD phosphatase subunit 1*  / reaction / complex
 ENSMUSG00000024369 Nelfe / P19426 / negative elongation factor complex member E, Rdbp / P18615* / negative elongation factor complex member E*  / reaction / complex






 

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