ENSMUSG00000024369


Mus musculus

Features
Gene ID: ENSMUSG00000024369
  
Biological name :Nelfe
  
Synonyms : negative elongation factor complex member E, Rdbp / Nelfe / P19426
  
Possible biological names infered from orthology : negative elongation factor complex member E / P18615
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34850391
Gene end: 34856372
  
Corresponding Affymetrix probe sets: 10444505 (MoGene1.0st)   1450705_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094956
Ensembl peptide - ENSMUSP00000131195
Ensembl peptide - ENSMUSP00000133934
Ensembl peptide - ENSMUSP00000134272
NCBI entrez gene - 27632     See in Manteia.
MGI - MGI:102744
RefSeq - NM_001045863
RefSeq - NM_001045864
RefSeq - NM_138580
RefSeq Peptide - NP_001039328
RefSeq Peptide - NP_001039329
RefSeq Peptide - NP_613046
swissprot - Q3UIA1
swissprot - G3UY39
swissprot - P19426
Ensembl - ENSMUSG00000024369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nelfeENSDARG00000004343Danio rerio
 NELFEENSG00000204356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR033102  Negative elongation factor E
 IPR034637  Negative elongation factor E, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032021 NELF complex ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020485 P63271 / Supt4a / suppressor of Ty 4A / P63272* / SUPT4H1* / SPT4 homolog, DSIF elongation factor subunit*  / complex / reaction
 ENSMUSG00000028330 Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*  / complex / reaction
 ENSMUSG00000033323 Ctdp1 / Q7TSG2 / RNA polymerase II subunit A C-terminal domain phosphatase / Q9Y5B0* / CTD phosphatase subunit 1*  / reaction / complex
 ENSMUSG00000003435 Supt5 / O55201 / Transcription elongation factor SPT5 / O00267* / SUPT5H* / SPT5 homolog, DSIF elongation factor subunit*  / reaction / complex
 ENSMUSG00000029111 Nelfa / Q8BG30 / Negative elongation factor A / Q9H3P2* / negative elongation factor complex member A*  / complex
 ENSMUSG00000022774 Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr