Manteia

ENSMUSG00000045983

Mus musculus

Features

Gene ID:	ENSMUSG00000045983

Biological name :	Eif4g1

Synonyms :	Eif4g1 / Eukaryotic translation initiation factor 4 gamma 1 / Q6NZJ6

Possible biological names infered from orthology :	Q04637

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	B1
Gene start:	20668313
Gene end:	20692884

Corresponding Affymetrix probe sets:	10434481 (MoGene1.0st) 1427036_a_at (Mouse Genome 430 2.0 Array) 1427037_at (Mouse Genome 430 2.0 Array) 1438686_at (Mouse Genome 430 2.0 Array) 1457150_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000111120 Ensembl peptide - ENSMUSP00000111117 Ensembl peptide - ENSMUSP00000111121 Ensembl peptide - ENSMUSP00000144594 Ensembl peptide - ENSMUSP00000144320 Ensembl peptide - ENSMUSP00000144233 Ensembl peptide - ENSMUSP00000144107 Ensembl peptide - ENSMUSP00000143999 Ensembl peptide - ENSMUSP00000143861 Ensembl peptide - ENSMUSP00000120698 Ensembl peptide - ENSMUSP00000120035 Ensembl peptide - ENSMUSP00000119215 Ensembl peptide - ENSMUSP00000117587 Ensembl peptide - ENSMUSP00000116029 Ensembl peptide - ENSMUSP00000115230 Ensembl peptide - ENSMUSP00000111123 Ensembl peptide - ENSMUSP00000047678 Ensembl peptide - ENSMUSP00000073506 NCBI entrez gene - 208643 See in Manteia. MGI - MGI:2384784 RefSeq - XM_017316920 RefSeq - NM_001304432 RefSeq - NM_145941 RefSeq - XM_006521935 RefSeq - XM_006521936 RefSeq - XM_006521937 RefSeq - XM_006521938 RefSeq - XM_006521939 RefSeq - XM_006521940 RefSeq - XM_006521942 RefSeq - XM_006521943 RefSeq - XM_006521944 RefSeq - XM_006521945 RefSeq - XM_006521946 RefSeq - XM_011245861 RefSeq - XM_017316919 RefSeq Peptide - NP_666053 RefSeq Peptide - NP_001291361 swissprot - E9Q770 swissprot - E9PVC6 swissprot - E9PVC5 swissprot - D6RCH1 swissprot - D3Z439 swissprot - D3YWY7 swissprot - D3YWM1 swissprot - D3YWC6 swissprot - A0A0J9YVC1 swissprot - A0A0J9YUS5 swissprot - A0A0J9YUL1 swissprot - A0A0J9YUC1 swissprot - A0A0J9YU44 swissprot - A0A0J9YTV0 swissprot - Q6NZJ6 swissprot - E9Q9E1 Ensembl - ENSMUSG00000045983

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CABZ01061894.1	ENSDARG00000116712	Danio rerio
eif4g1a	ENSDARG00000006200	Danio rerio
EIF4G1	ENSGALG00000008520	Gallus gallus
EIF4G1	ENSG00000114867	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Eif4g3 / Mus musculus eukaryotic translation initiation factor 4 gamma, 3 (Eif4g3), transcript variant 4, mRNA. / O43432* / eukaryotic translation initiation factor 4 gamma 3*	ENSMUSG00000028760	46
Eif4g2 / eukaryotic translation initiation factor 4 gamma 2 isoform 2 / P78344* / eukaryotic translation initiation factor 4 gamma 2*	ENSMUSG00000005610	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR003307	W2 domain
IPR003890	MIF4G-like, type 3
IPR003891	Initiation factor eIF-4 gamma, MA3
IPR016024	Armadillo-type fold
IPR037584	Eukaryotic translation initiation factor 4 gamma 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001662	behavioral fear response	IGI
biological_process	GO:0006412	translation	ISO
biological_process	GO:0006413	translational initiation	IEA
biological_process	GO:0006417	regulation of translation	IEA
biological_process	GO:0006446	regulation of translational initiation	IEA
biological_process	GO:0007005	mitochondrion organization	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0010507	negative regulation of autophagy	IEA
biological_process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	IEA
biological_process	GO:0010942	positive regulation of cell death	IEA
biological_process	GO:0030307	positive regulation of cell growth	IEA
biological_process	GO:0031669	cellular response to nutrient levels	IEA
biological_process	GO:0032270	positive regulation of cellular protein metabolic process	IEA
biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA
biological_process	GO:0034645	cellular macromolecule biosynthetic process	IEA
biological_process	GO:0045666	positive regulation of neuron differentiation	IMP
biological_process	GO:0097009	energy homeostasis	IEA
biological_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IEA
biological_process	GO:1905537	positive regulation of eukaryotic translation initiation factor 4F complex assembly	IEA
biological_process	GO:1905606	regulation of presynapse assembly	IEA
biological_process	GO:1905612	positive regulation of mRNA cap binding	IEA
biological_process	GO:1905618	positive regulation of miRNA mediated inhibition of translation	IEA
biological_process	GO:1905696	regulation of polysome binding	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005844	polysome	IEA
cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0003729	mRNA binding	IEA
molecular_function	GO:0003743	translation initiation factor activity	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008135	translation factor activity, RNA binding	IEA
molecular_function	GO:0008190	eukaryotic initiation factor 4E binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA

Pathways (from Reactome)

Pathway description

ISG15 antiviral mechanism

mTORC1-mediated signalling

Deadenylation of mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

Ribosomal scanning and start codon recognition

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Clec7a^tm1.1Bpip/Clec7a^tm1.1Bpip,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020516	Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*	/ reaction
ENSMUSG00000093661	Eif4e3 / Q9DBB5 / Eukaryotic translation initiation factor 4E type 3 / Q8N5X7* / eukaryotic translation initiation factor 4E family member 3*	/ complex
ENSMUSG00000025580	Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*	/ complex
ENSMUSG00000022774	Ncbp2 / Q9CQ49 / Nuclear cap-binding protein subunit 2 / P52298*	/ complex
ENSMUSG00000025234	Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*	/ reaction
ENSMUSG00000028330	Ncbp1 / Q3UYV9 / Nuclear cap-binding protein subunit 1 / Q09161*	/ complex
ENSMUSG00000027078	Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*	/ reaction
ENSMUSG00000059796	Eif4a1 / P60843 / Eukaryotic initiation factor 4A-I / P60842* / eukaryotic translation initiation factor 4A1*	/ complex
ENSMUSG00000035692	Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*	/ reaction
ENSMUSG00000051732	Pabpc2 / P11940* / PABPC1* / poly(A) binding protein cytoplasmic 1*	/ complex
ENSMUSG00000094973	Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*	/ complex
ENSMUSG00000026254	Eif4e2 / Q8BMB3 / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA. / O60573* / eukaryotic translation initiation factor 4E family member 2*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr