ENSMUSG00000020516


Mus musculus

Features
Gene ID: ENSMUSG00000020516
  
Biological name :Rps6kb1
  
Synonyms : Q8BSK8 / ribosomal protein S6 kinase, polypeptide 1 / Rps6kb1
  
Possible biological names infered from orthology : P23443 / ribosomal protein S6 kinase B1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 86498871
Gene end: 86544805
  
Corresponding Affymetrix probe sets: 10389484 (MoGene1.0st)   1428849_at (Mouse Genome 430 2.0 Array)   1446376_at (Mouse Genome 430 2.0 Array)   1454956_at (Mouse Genome 430 2.0 Array)   1457562_at (Mouse Genome 430 2.0 Array)   1459951_at (Mouse Genome 430 2.0 Array)   1460705_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053188
Ensembl peptide - ENSMUSP00000119715
Ensembl peptide - ENSMUSP00000122756
NCBI entrez gene - 72508     See in Manteia.
MGI - MGI:1270849
RefSeq - XM_017314793
RefSeq - NM_001114334
RefSeq - NM_028259
RefSeq - XM_006534315
RefSeq - XM_011249275
RefSeq - XM_011249276
RefSeq - XM_017314791
RefSeq - XM_017314792
RefSeq - XM_006534314
RefSeq Peptide - NP_082535
RefSeq Peptide - NP_001107806
swissprot - Q5SWG2
swissprot - Q8BSK8
swissprot - Q8C3J7
Ensembl - ENSMUSG00000020516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6kb1aENSDARG00000018399Danio rerio
 rps6kb1bENSDARG00000058230Danio rerio
 RPS6KB1ENSGALG00000005198Gallus gallus
 P23443ENSG00000108443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*ENSMUSG0000002483064
P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*ENSMUSG0000003130942
Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / Q9UK32* / ribosomal protein S6 kinase A6*ENSMUSG0000002566541
Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*ENSMUSG0000002380941
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364441
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118039
Q9Z2B9 / Rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / ribosomal protein S6 kinase A4*ENSMUSG0000002495238
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995422
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598121
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016238  Ribosomal protein S6 kinase
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001662 behavioral fear response IGI
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IBA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043491 protein kinase B signaling IGI
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045948 positive regulation of translational initiation IEA
 biological_processGO:0046324 regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0048633 positive regulation of skeletal muscle tissue growth IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: involves: 129P2/OlaHsd * MRL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Allelic Composition: Eprstm2.1Xen/Eprstm2.1Xen,Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Nte/Rps6kb1tm1Nte
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: B6.129P2-Rps6kb1tm1Gtho Rps6kb2tm1Gtho

Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014173 increased fatty acid beta-oxidation "increased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Rps6kb2tm1Gtho/Rps6kb2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028495 Rps6 / P62754 / 40S ribosomal protein S6 / P62753* / ribosomal protein S6*  / reaction
 ENSMUSG00000045983 Eif4g1 / Q6NZJ6 / Eukaryotic translation initiation factor 4 gamma 1 / Q04637*  / reaction
 ENSMUSG00000035064 Eef2k / O08796 / Eukaryotic elongation factor 2 kinase / O00418*  / reaction
 ENSMUSG00000058655 Eif4b / Q8BGD9 / Eukaryotic translation initiation factor 4B / P23588*  / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction






 

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