ENSMUSG00000028495


Mus musculus

Features
Gene ID: ENSMUSG00000028495
  
Biological name :Rps6
  
Synonyms : 40S ribosomal protein S6 / P62754 / Rps6
  
Possible biological names infered from orthology : P62753 / ribosomal protein S6
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 86854660
Gene end: 86857412
  
Corresponding Affymetrix probe sets: 10363699 (MoGene1.0st)   10421571 (MoGene1.0st)   10424823 (MoGene1.0st)   10446821 (MoGene1.0st)   10483806 (MoGene1.0st)   10514233 (MoGene1.0st)   10573821 (MoGene1.0st)   10604904 (MoGene1.0st)   1416141_a_at (Mouse Genome 430 2.0 Array)   1416142_at (Mouse Genome 430 2.0 Array)   1434377_x_at (Mouse Genome 430 2.0 Array)   1435816_at (Mouse Genome 430 2.0 Array)   1435817_x_at (Mouse Genome 430 2.0 Array)   1435962_at (Mouse Genome 430 2.0 Array)   1437246_x_at (Mouse Genome 430 2.0 Array)   1453466_at (Mouse Genome 430 2.0 Array)   1454620_x_at (Mouse Genome 430 2.0 Array)   1455693_x_at (Mouse Genome 430 2.0 Array)   1455981_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099878
NCBI entrez gene - 105244208     See in Manteia.
NCBI entrez gene - 20104     See in Manteia.
MGI - MGI:98159
RefSeq - NM_009096
RefSeq Peptide - NP_033122
swissprot - P62754
swissprot - Q5BLK1
Ensembl - ENSMUSG00000028495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ENSDARG00000019778Danio rerio
 RPS6ENSGALG00000015082Gallus gallus
 RPS6ENSG00000137154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001377  Ribosomal protein S6e
 IPR014401  Ribosomal protein S6, eukaryotic
 IPR018282  Ribosomal protein S6e, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0002309 T cell proliferation involved in immune response IMP
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006924 activation-induced cell death of T cells IMP
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0022605 mammalian oogenesis stage IMP
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0042274 ribosomal small subunit biogenesis IEA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0048821 erythrocyte development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IDA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0015935 small ribosomal subunit IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6tm1Om/Rps6tm1Om
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020516 Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*  / reaction






 

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