ENSG00000137154


Homo sapiens

Features
Gene ID: ENSG00000137154
  
Biological name :RPS6
  
Synonyms : P62753 / ribosomal protein S6 / RPS6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p22.1
Gene start: 19375715
Gene end: 19380254
  
Corresponding Affymetrix probe sets: 200081_s_at (Human Genome U133 Plus 2.0 Array)   201254_x_at (Human Genome U133 Plus 2.0 Array)   209134_s_at (Human Genome U133 Plus 2.0 Array)   211690_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369741
Ensembl peptide - ENSP00000369757
Ensembl peptide - ENSP00000369745
Ensembl peptide - ENSP00000369743
NCBI entrez gene - 6194     See in Manteia.
OMIM - 180460
RefSeq - NM_001010
RefSeq Peptide - NP_001001
swissprot - A2A3R7
swissprot - A2A3R6
swissprot - A2A3R5
swissprot - P62753
Ensembl - ENSG00000137154
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ENSDARG00000019778Danio rerio
 RPS6ENSGALG00000015082Gallus gallus
 Rps6ENSMUSG00000028495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001377  Ribosomal protein S6e
 IPR014401  Ribosomal protein S6, eukaryotic
 IPR018282  Ribosomal protein S6e, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002309 T cell proliferation involved in immune response IEA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0006924 activation-induced cell death of T cells IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0022605 mammalian oogenesis stage IEA
 biological_processGO:0031929 TOR signaling IDA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0042274 ribosomal small subunit biogenesis IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0048821 erythrocyte development IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0015935 small ribosomal subunit IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
mTORC1-mediated signalling
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108443 P23443 / RPS6KB1 / ribosomal protein S6 kinase B1  / reaction






 

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