ENSMUSG00000023809


Mus musculus

Features
Gene ID: ENSMUSG00000023809
  
Biological name :Rps6ka2
  
Synonyms : Q9WUT3 / ribosomal protein S6 kinase, polypeptide 2 / Rps6ka2
  
Possible biological names infered from orthology : Q15349 / ribosomal protein S6 kinase A2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 7170115
Gene end: 7303313
  
Corresponding Affymetrix probe sets: 10441565 (MoGene1.0st)   1417542_at (Mouse Genome 430 2.0 Array)   1417543_at (Mouse Genome 430 2.0 Array)   1441311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024575
NCBI entrez gene - 20112     See in Manteia.
MGI - MGI:1342290
RefSeq - XM_006523201
RefSeq - NM_011299
RefSeq - XM_006523199
RefSeq - XM_006523200
RefSeq - XM_006523198
RefSeq Peptide - NP_035429
swissprot - Q9WUT3
Ensembl - ENSMUSG00000023809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps6ka2ENSDARG00000028469Danio rerio
 RPS6KA2ENSGALG00000011473Gallus gallus
 Q15349ENSG00000071242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*ENSMUSG0000003130980
P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*ENSMUSG0000000364478
Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / Q9UK32* / ribosomal protein S6 kinase A6*ENSMUSG0000002566572
Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*ENSMUSG0000002118043
Q9Z2B9 / Rps6ka4 / ribosomal protein S6 kinase, polypeptide 4 / O75676* / ribosomal protein S6 kinase A4*ENSMUSG0000002495242
Q8BSK8 / Rps6kb1 / ribosomal protein S6 kinase, polypeptide 1 / P23443* / ribosomal protein S6 kinase B1*ENSMUSG0000002051630
Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*ENSMUSG0000002483027
Q8BGW6 / Stk32a / Serine/threonine-protein kinase 32A / Q8WU08* / serine/threonine kinase 32A*ENSMUSG0000003995417
Q9JJX8 / Stk32b / Serine/threonine-protein kinase 32B / Q9NY57* / serine/threonine kinase 32B*ENSMUSG0000002912317
Q8QZV4 / Stk32c / Serine/threonine-protein kinase 32C / Q86UX6* / serine/threonine kinase 32C*ENSMUSG0000001598117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016239  Ribosomal protein S6 kinase II
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IDA
 biological_processGO:0002035 brain renin-angiotensin system IDA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007507 heart development IDA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0045786 negative regulation of cell cycle ISS
 biological_processGO:0045835 negative regulation of meiotic nuclear division IDA
 biological_processGO:0060047 heart contraction IDA
 biological_processGO:0070613 regulation of protein processing IMP
 biological_processGO:0071322 cellular response to carbohydrate stimulus IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004711 ribosomal protein S6 kinase activity IDA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
CREB phosphorylation through the activation of Ras
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction






 

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